...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Experimental and clinical endocrinology and diabetes: Official journal, German Society of Endocrinology [and] German Diabetes Association >Management and outcome of severe diabetic foot infections.
【24h】

Management and outcome of severe diabetic foot infections.

机译：严重糖尿病足感染的管理和结果。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We evaluated the bacteriological and clinical efficacy of the combination of ciprofloxacin/clindamycin in severe diabetic foot infections and we tried to elucidate the relationship between the vascular status of the lower limbs and the outcome of these infections. Initial empirical antibiotic therapy with ciprofloxacin (300 mg/12 hrs IV) and clindamycin (600 mg/8 hrs IV) was administered in 84 hospitalized diabetics with severe lower limb infections. This treatment was continued only in cases with primary clinical improvement. The major endpoints of treatment were: cure, improvement and failure. Evaluation of the vascular status of the lower extremities was performed by high resolution imaging coloured ultrasonography, US-Doppler and TcPO2 measurements. Polymicrobial flora was found in 83% of the cases with an average 2.8 species per specimen. Osteomyelitis was detected in 58 % of the patients. After five days of IV administration of ciprofloxacin and clindamycin the response rate was 95.2%. After three weeks of therapy the clinical outcome was: cure 54.8%, improvement 23.8%, and failure 21.4%. The long term follow up (mean duration 16 months) revealed complete healing of the skin lesions in 63 patients (75%). Unfavorable prognostic factors for these infections were: ankle systolic blood pressure <50 mmHg or toe systolic blood pressure < 30 mmHg and TcPO2 < 20 mmHg. The side effects of the combination of ciprofloxacin/clindamycin were mild and there were no cases of pseudomembranous enterocolitis. The combination of ciprofloxacin/clindamycin was found to provide an excellent empirical as well as definitive treatment of severe diabetic foot infections. The evaluation of the vascular status and the severity of ischaemia of the lower limbs has a strong predictive value in the outcome of these infections.
机译：我们评估了环丙沙星/克林霉素在严重糖尿病足感染中的细菌学和临床疗效，并试图阐明下肢血管状态与这些感染结果之间的关系。在84例严重下肢感染住院的糖尿病患者中，采用环丙沙星（300 mg / 12 hrs IV）和克林霉素（600 mg / 8 hrs IV）进行了初步的经验性抗生素治疗。仅在具有主要临床改善的情况下才继续使用该治疗。治疗的主要终点是：治愈，改善和失败。通过高分辨率成像彩色超声检查，US-Doppler和TcPO2测量来评估下肢的血管状态。在83％的病例中发现了多菌种，每个标本平均有2.8种。在58％的患者中发现了骨髓炎。静脉注射环丙沙星和克林霉素五天后，缓解率为95.2％。治疗三周后，临床结果为：治愈54.8％，改善23.8％，失败21.4％。长期随访（平均持续时间16个月）显示63例患者（75％）的皮肤病变完全愈合。这些感染的不利预后因素为：踝部收缩压<50 mmHg或脚趾收缩压<30 mmHg和TcPO2 <20 mmHg。环丙沙星/克林霉素联合使用的副作用较轻，没有假膜性小肠结肠炎病例。发现环丙沙星/克林霉素的组合可为严重的糖尿病足感染提供出色的经验和确定性治疗。对下肢缺血性血管状态和严重程度的评估对这些感染的结果具有很强的预测价值。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号