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首页> 外文期刊>Experimental & Molecular Pathology >The HIF1A rs2057482 polymorphism is associated with risk of developing premature coronary artery disease and with some metabolic and cardiovascular risk factors. The Genetics of Atherosclerotic Disease (GEA) Mexican Study
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The HIF1A rs2057482 polymorphism is associated with risk of developing premature coronary artery disease and with some metabolic and cardiovascular risk factors. The Genetics of Atherosclerotic Disease (GEA) Mexican Study

机译：HIF1A rs2057482多态性与发生早发冠状动脉疾病的风险以及某些代谢和心血管危险因素有关。墨西哥动脉粥样硬化疾病的遗传学研究

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摘要

The aim of the present study was to establish the role of HIF1A gene polymorphisms in the risk of developing premature coronary artery disease (CAD) in a well-characterized clinical cohort. Three polymorphisms in HIF1A (rs11549465, rs11549467, rs2057482) gene were genotyped in 949 patients with premature CAD, and 676 healthy controls (with negative calcium score by computed tomography). Under a dominant model adjusted for age, visceral to subcutaneous adipose tissue (VAT/SAT) ratio, hypertension, type 2 diabetes mellitus (T2DM), HDL-C levels, hypercholesterolemia and hypertriglyceridemia, the rs2057482 T allele was associated with decreased risk of premature CAD when compared to healthy controls (OR=0.616, Pdom=0.020). The effect of the studied polymorphisms on various metabolic parameters and cardiovascular risk factors was explored. In this analysis, the rs2057482 T allele was associated with decreased risk of obesity, central obesity, hypertension, hypercholesterolemia, hypertriglyceridemia and increased risk of T2DM. Under a dominant model adjusted by age, the HIF1A rs2057482 T polymorphism was associated with high VAT/SAT ratio (P=0.009) and HDL-C levels (P=0.04) in healthy controls. The results suggest that HIF1A rs2057482 polymorphism is involved in the risk of developing CAD and is associated with some metabolic parameters and cardiovascular risk factors.
机译：本研究的目的是在一个特征明确的临床队列中确定HIF1A基因多态性在发生早发冠状动脉疾病（CAD）的风险中的作用。在949例早发CAD患者和676例健康对照者（计算机断层扫描钙化评分为阴性）中对HIF1A基因的三个多态性（rs11549465，rs11549467，rs2057482）进行了基因分型。在针对年龄，内脏至皮下脂肪组织（VAT / SAT）比率，高血压，2型糖尿病（T2DM），HDL-C水平，高胆固醇血症和高甘油三酯血症进行校正的优势模型下，rs2057482 T等位基因与降低早产风险相关与健康对照组比较时的CAD（OR = 0.616，Pdom = 0.020）。探索了研究的多态性对各种代谢参数和心血管危险因素的影响。在该分析中，rs2057482 T等位基因与肥胖，中枢性肥胖，高血压，高胆固醇血症，高甘油三酯血症的风险降低和T2DM的风险增加相关。在按年龄调整的显性模型下，健康对照者的HIF1A rs2057482 T多态性与高VAT / SAT比（P = 0.009）和HDL-C水平（P = 0.04）相关。结果表明，HIF1A rs2057482多态性与发展为CAD的风险有关，并且与某些代谢参数和心血管危险因素有关。

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