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首页> 外文期刊>Experimental & Molecular Pathology >Clinical implication of leucine zipper/EF hand-containing transmembrane-1 overexpression in the prognosis of triple-negative breast cancer
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Clinical implication of leucine zipper/EF hand-containing transmembrane-1 overexpression in the prognosis of triple-negative breast cancer

机译：亮氨酸拉链/ EF手跨膜1过表达在三阴性乳腺癌预后中的临床意义

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摘要

Triple negative breast cancer (TNBC) is a heterogeneous disease with higher rates of relapse and decreased overall survival in metastatic tumors. Due to its poor prognosis, it is necessary to identify effective biomarkers that are associated with tumor growth and metastasis. The leucine zipper/EF hand-containing transmembrane-1 (LETM1) protein, which is a mitochondrial inner membrane protein, can reduce mitochondrial biogenesis and ATP production. The expression levels of LETM1 were significantly increased in numerous human malignancies. However, the clinicopathological characteristics and prognostic value of LETM1 overexpression in TNBC remains unclear. LETM1 protein was detected in 107 TNBC, 42 ductal carcinoma in situ (DCIS) and 65 adjacent non-tumor breast tissues using immunohistochemical (IHC) staining. Immunofluorescence (IF) staining was also performed to detect the localization of LETM1 protein in MCF-7 BC cells. The correlations between LETM1 overexpression and clinicopathological features of TNBC were evaluated using Chi-squared test and Fisher's exact tests. The survival rate was calculated using the Kaplan-Meier method. LETM1 protein showed cytoplasmic staining patterns in TNBC. The strongly positive rate of LETM1 in TNBC was 69.2% (74/107), which was significantly higher than in both DCIS 35.7% (15/42) and adjacent non-tumor tissues 12.3% (8/65). High-level expression of LETM1 was positively correlated with late clinical stage, poor differentiation, lymph node metastasis, disease-free survival (DFS) and 10-year overall survival (OS) rates in TNBC. Further analysis showed that high LETM1 expression along with clinical stage emerged as significant independent risk factors in patients with TNBC. In conclusion, LETM1 protein overexpression is associated with TNBC progression, and may be a potential biomarker for poor prognostic evaluation of TNBC. (C) 2015 Elsevier Inc. All rights reserved.
机译：三阴性乳腺癌（TNBC）是一种异质性疾病，在转移性肿瘤中复发率较高且总体生存率下降。由于其不良预后，有必要鉴定与肿瘤生长和转移相关的有效生物标志物。亮氨酸拉链/ EF手跨膜1（LETM1）蛋白是线粒体内膜蛋白，可减少线粒体的生物发生和ATP的产生。在许多人类恶性肿瘤中，LETM1的表达水平显着增加。然而，TNBC中LETM1过表达的临床病理特征和预后价值仍不清楚。使用免疫组织化学（IHC）染色在107 TNBC，42导管原位癌（DCIS）和65相邻的非肿瘤乳腺组织中检测到LETM1蛋白。还进行了免疫荧光（IF）染色以检测LEF1蛋白在MCF-7 BC细胞中的定位。使用卡方检验和Fisher精确检验评估LETM1过表达与TNBC临床病理特征之间的相关性。使用Kaplan-Meier方法计算存活率。 LETM1蛋白在TNBC中显示出细胞质染色模式。 TNBC中LETM1的强阳性率为69.2％（74/107），显着高于DCIS的35.7％（15/42）和邻近的非肿瘤组织的12.3％（8/65）。 TNBC中LETM1的高水平表达与临床晚期，分化差，淋巴结转移，无病生存率（DFS）和10年总生存率（OS）呈正相关。进一步的分析表明，高LETM1表达和临床分期已成为TNBC患者的重要独立危险因素。总之，LETM1蛋白的过表达与TNBC的进展有关，并且可能是TNBC不良预后评估的潜在生物标志物。 （C）2015 Elsevier Inc.保留所有权利。

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