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CrAg lateral flow assay for cryptococcosis

机译：CrAg侧流法用于隐球菌病

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Importance of field: Cryptococcal meningitis is a leading cause of death globally among people with AIDS. In sub-Saharan Africa, cryptococcosis is estimated to kill more people than tuberculosis. Cryptococcosis is also an important infectious disease among immunosuppressed patients in countries with advanced medical care. Early diagnosis is the key to effective treatment, particularly in patients in resource-limited settings. A new lateral flow immunoassay (LFA) for cryptococcal antigen (CrAg) allows for rapid and inexpensive diagnosis of cryptococcosis at or near the point of patient contact. Areas covered: This article reviews the need for improved diagnostics for cryptococcal meningitis and describes the features of an ideal diagnostic. The design of a new LFA for CrAg is described as well as the results of initial clinical evaluation of the CrAg LFA. Expert opinion: The CrAg LFA is recommended for use with serum, plasma or CSF for diagnosis of cryptococcal meningitis or non-meningeal cryptococcal disease in symptomatic patients. There is a need for further evaluation of LFA for screening of asymptomatic patients. However, the LFA is emerging as a valuable tool for screening of serum or plasma in ART-naive adults with CD4 counts less than 100 cells/mm 3 in geographic regions with a high prevalence of cryptococcal antigenemia. CrAg screening has the potential to identify patients with asymptomatic cryptococcal infection who should receive preemptive antifungal therapy.
机译：领域的重要性：隐球菌性脑膜炎是全球艾滋病患者死亡的主要原因。在撒哈拉以南非洲，据估计，隐球菌比结核病杀死的人更多。在先进医疗保健国家中，隐球菌病也是免疫抑制患者中的一种重要传染病。早期诊断是有效治疗的关键，尤其是在资源有限的患者中。一种针对隐球菌抗原（CrAg）的新的侧向流免疫测定法（LFA），可以在患者接触点或附近快速，廉价地诊断隐球菌。涵盖的领域：本文回顾了对隐球菌性脑膜炎的改进诊断方法的需求，并介绍了理想诊断方法的功能。描述了一种新的CrAg LFA的设计以及CrAg LFA的初始临床评估结果。专家意见：CrAg LFA建议与血清，血浆或CSF一起用于有症状患者的隐球菌性脑膜炎或非脑膜隐球菌病的诊断。需要进一步评估LFA，以筛查无症状患者。然而，LFA逐渐成为一种有价值的工具，可用于在初生成人中，在隐球菌抗原血症高发的地理区域中，CD4计数低于100细胞/ mm 3的成年人中筛查血清或血浆。 CrAg筛查有潜力识别无症状隐球菌感染患者，这些患者应接受先发性抗真菌治疗。

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