...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Expert opinion on medical diagnostics. >Molecular diagnosis of parathyroid carcinoma:--a reality in the near future
【24h】

Molecular diagnosis of parathyroid carcinoma:--a reality in the near future

机译：甲状旁腺癌的分子诊断：-在不久的将来成为现实

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Introduction: Parathyroid carcinoma (PC) is a rare endocrine malignancy that still suffers from a problem of delayed clinical diagnosis. Consequently, it usually is not recognized preoperatively and often is not conclusively identified during the operation either.Areas covered: The role played by parafibromin in the development of PC, representing an important advance in understanding the pathogenesis of this malignancy, is discussed. Through a careful search of the international literature, using "parathyroid carcinoma", "molecular genetics of parathyroid carcinoma" and "parathyroid tumorigenesis" as key words, other less mentioned molecular mechanisms are reappraised as potential molecular markers of PC; we also discuss their potential role in 20 parathyroid outgrowths. Finally, both the major efforts and the limitations of reported molecular diagnostic techniques and diagnostic markers are considered. Expert opinion: Currently, several critical issues still need to be addressed, such as the lack of: i) common criteria for the histopathological diagnosis of parathyroid malignancy and ii) timely appropriated preoperative diagnosis of PC. The latter issue would be of fundamental importance to assist the surgeon in performing a complete resection of all carcinomatous tissue at the time of the initial surgery, allowing for the greatest likelihood of a cure.
机译：简介：甲状旁腺癌（PC）是一种罕见的内分泌恶性肿瘤，仍然存在临床诊断延迟的问题。因此，它通常在术前不能被识别，而且在手术中也常常不能最终确定。覆盖范围：讨论了副纤蛋白在PC发育中的作用，代表了在理解这种恶性肿瘤发病机理方面的重要进展。通过对国际文献的仔细研究，以“甲状旁腺癌”，“甲状旁腺癌的分子遗传学”和“甲状旁腺肿瘤发生”为关键词，其他未被提及的分子机制被重新评价为PC的潜在分子标记。我们还将讨论它们在20种甲状旁腺增生中的潜在作用。最后，考虑了已报道的分子诊断技术和诊断标记的主要努力和局限性。专家意见：当前，仍需要解决几个关键问题，例如，缺乏：i）甲状旁腺恶性肿瘤组织病理学诊断的通用标准; ii）术前及时诊断PC。后一个问题对于协助外科医生在初次手术时对所有癌组织进行完整切除具有至关重要的意义，从而最大可能地治愈了。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号