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首页> 外文期刊>Expert opinion on medical diagnostics. >Hyperpolarized 13C-pyruvate magnetic resonance imaging in cancer diagnostics
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Hyperpolarized 13C-pyruvate magnetic resonance imaging in cancer diagnostics

机译：超极化13C-丙酮酸磁共振成像在癌症诊断中的作用

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Introduction: The use of hyperpolarized molecules allows one to obtain information about metabolism in both cells and animals; such a task represents a tremendous advancement with respect to the results achieved so far with in vivo NMR techniques. Pyruvate appears an excellent tumor biomarker as it allows the attainment of early diagnosis, stadiation and monitoring of response to therapy. Areas covered: As pyruvate conversion to lactate in the glycolytic pathway is highly enhanced in tumor cells, the 1- 13C-lactate levels after administration of hyperpolarized 1- 13C-pyruvate are markedly higher in tumor tissues and depend on the type and grade of the tumor. This review covers the most recent research results (both in vitro and in vivo) about the use of hyperpolarized 1- 13C-pyruvate for tumor localization, stadiation and for monitoring the response to therapy. The technique may find application in clinics, especially when other imaging modalities are of difficult applicability. Expert opinion: While 13C-pyruvate has been shown to be the candidate of choice for metabolic imaging, high expectations are present in the scientific community to see if other hyperpolarized substrates could provide more specific and sensitive biomarkers. The use of hyperpolarized molecules will have a tremendous impact in the armory of diagnostic tools.
机译：简介：使用超极化分子可以使人们获得有关细胞和动物体内新陈代谢的信息。相对于迄今为止使用体内NMR技术获得的结果而言，这一任务代表了巨大的进步。丙酮酸似乎是极好的肿瘤生物标志物，因为它可以实现早期诊断，稳定和监测对治疗的反应。涵盖的区域：由于肿瘤细胞中丙酮酸在糖酵解途径中转化为乳酸的程度大大提高，因此在肿瘤组织中施用超极化的1-13C-丙酮酸后，其1-13C-乳酸水平明显更高，这取决于肿瘤的类型和等级。瘤。这篇综述涵盖了关于使用超极化的1- 13C-丙酮酸盐进行肿瘤定位，稳定和监测对治疗反应的最新研究结果（体外和体内）。该技术可能在临床中得到应用，尤其是在其他成像方式难以应用时。专家意见：虽然13C-丙酮酸已被证明是代谢成像的首选，但科学界对其他超极化底物能否提供更特异性和敏感性的生物标记物抱有很高的期望。超极化分子的使用将对诊断工具的军备产生巨大影响。

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