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首页> 外文期刊>Expert opinion on medical diagnostics. >Recent biomarkers for the identification of patients at risk for preeclampsia: The role of uteroplacental ischemia
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Recent biomarkers for the identification of patients at risk for preeclampsia: The role of uteroplacental ischemia

机译：用于识别先兆子痫高危患者的最新生物标志物：子宫胎盘缺血的作用

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Introduction: The prediction and early diagnosis of preeclampsia remains limited due to its heterogeneous clinical presentation and unclear pathophysiology. However, accumulating evidence indicates that angiogenic imbalances during pregnancy may play a central role in the mechanisms of injury of preeclampsia. Moreover, a growing body of evidence suggests that a combination of biochemical and biophysical parameters in the first and second trimester may contribute to the identification of patients at high risk of early-onset and/or severe preeclampsia. Areas covered: This article reviews proposed mechanisms of injury in preeclampsia as well as recent attempts in the prediction of this pregnancy complication. The article also highlights the limitations of these studies, in particular their low positive predictive value, indicating that any prophylactic intervention would expose a large number of patients who would not develop the disease. Expert opinion: The prediction of early-onset preeclampsia using biochemical and biophysical parameters or the combination of both is in general better than the prediction of late-onset preeclampsia. We propose a conceptual framework whereby the timing of presentation of preeclampsia may be a function of the timing of the insults to the fetal supply line as well as a function of the fetal response to these insults.
机译：简介：由于先兆子痫的临床表现不均且病理生理尚不清楚，因此其预测和早期诊断仍然有限。但是，越来越多的证据表明，怀孕期间的血管生成失衡可能在先兆子痫的损伤机制中起着核心作用。此外，越来越多的证据表明，在孕早期和孕中期生化和生物物理参数的组合可能有助于识别早期发作和/或严重先兆子痫高风险的患者。涵盖的领域：本文回顾了先兆子痫的拟议损伤机制以及最近对这种妊娠并发症进行预测的尝试。文章还强调了这些研究的局限性，特别是它们的低阳性预测值低，表明任何预防性干预措施都会暴露出大量不会患该病的患者。专家意见：使用生化和生物物理参数或两者结合来预测先兆子痫前期通常比先兆子痫前期的预测更好。我们提出了一个概念框架，其中先兆子痫的出现时间可能是对胎儿供应线的侮辱时间的函数，也是对这些侮辱的胎儿反应的函数。

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