Effects of montelukast-desloratadine combination on early and late asthma responses Davis BE, Illamperuma C, Gauvreau GM, et al. Single-dose desloratadine and montelukast and allergen-induced late airway responses. Eur Respir J 2009;33(6):1302-308.

Antoniu SA

首页> 外文期刊>Expert opinion on pharmacotherapy >Effects of montelukast-desloratadine combination on early and late asthma responses Davis BE, Illamperuma C, Gauvreau GM, et al. Single-dose desloratadine and montelukast and allergen-induced late airway responses. Eur Respir J 2009;33(6):1302-308.

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Effects of montelukast-desloratadine combination on early and late asthma responses Davis BE, Illamperuma C, Gauvreau GM, et al. Single-dose desloratadine and montelukast and allergen-induced late airway responses. Eur Respir J 2009;33(6):1302-308.

机译：孟鲁司特-去氯雷他定联合治疗对早期和晚期哮喘反应的影响Davis BE，Illamperuma C，Gauvreau GM等。单剂量地氯雷他定和孟鲁司特以及过敏原引起的晚期气道反应。 Eur Respir J 2009; 33（6）：1302-308。

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BACKGROUND: In asthma, montelukast is given on regular basis to reduce eosinophilic airway inflammation. Addition of the antihistaminic desloratadine can amplify the early and late anti-inflammatory activities of montelukast in patients with asthma. OBJECTIVE: To assess the efficacy data of preventive single-dose desloratadine, montelukast and combination therapy in asthma subjects challenged with inhaled allergens. METHODS/RESULTS: Analysis of data from a placebo-controlled, cross-over study in which combination preventive therapy was demonstrated to be superior in reducing both early and late allergen-induced inflammatory response when compared with placebo and each component. CONCLUSION: Although such combination therapy might be effective in preventing the inflammatory flare following the transient allergen exposure, further studies are needed to better define such therapy in terms of duration, doses and therapeutic indications.

机译：背景：在哮喘中，应定期服用孟鲁司特以减少嗜酸性气道炎症。抗组胺地氯雷他定的添加可以增强孟鲁司特在哮喘患者中的早期和晚期抗炎活性。目的：评估预防性单剂量去氯雷他定，孟鲁司特和联合治疗在吸入性过敏原激发的哮喘患者中的疗效数据。方法/结果：一项安慰剂对照，交叉研究的数据分析表明，与安慰剂和每种成分相比，联合预防治疗在减少早期和晚期变应原诱导的炎症反应方面具有优势。结论：尽管这种联合疗法可能有效预防短暂性变应原暴露后的炎症发作，但仍需要进一步研究以从持续时间，剂量和治疗适应症方面更好地界定此类疗法。

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《Expert opinion on pharmacotherapy》 |2009年第15期|共3页
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Antoniu SA;
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1. Effects of montelukast-desloratadine combination on early and late asthma responses Davis BE, Illamperuma C, Gauvreau GM, et al. Single-dose desloratadine and montelukast and allergen-induced late airway responses. Eur Respir J 2009;33(6):1302-308. [J] . Antoniu SA Expert opinion on pharmacotherapy . 2009,第15期

机译：孟鲁司特-去氯雷他定联合治疗对早期和晚期哮喘反应的影响Davis BE，Illamperuma C，Gauvreau GM等。单剂量地氯雷他定和孟鲁司特以及过敏原引起的晚期气道反应。 Eur Respir J 2009; 33（6）：1302-308。
2. Effects of montelukast-desloratadine combination on early and late asthma responses Davis BE, Illamperuma C, Gauvreau GM, et al. Single-dose desloratadine and montelukast and allergen-induced late airway responses. Eur Respir J 2009;33(6):1302-308. [J] . Antoniu SA Expert opinion on pharmacotherapy . 2009,第15期

机译：孟鲁斯特 - 斯托拉汀组合在早期和晚期哮喘响应戴维斯的影响，伊拉克鲁姆C，Gauvreau Gm等。单剂量去氯丁和蒙特洛特和过敏原诱导的后期气道反应。 EUR RESPIR J 2009; 33（6）：1302-308。
3. Effects of montelukast-desloratadine combination on early and late asthma responses Davis BE, Illamperuma C, Gauvreau GM, et al. Single-dose desloratadine and montelukast and allergen-induced late airway responses. Eur Respir J 2009;33(6):1302-308. [J] . Antoniu SA Expert opinion on pharmacotherapy . 2009,第15期

机译：孟鲁斯特 - 斯托拉汀组合在早期和晚期哮喘响应戴维斯的影响，伊拉克鲁姆C，Gauvreau Gm等。单剂量去氯丁和蒙特洛特和过敏原诱导的后期气道反应。 EUR RESPIR J 2009; 33（6）：1302-308。
4. Effect of the 5-lipoxygenase inhibitor ZD2138 on allergen-induced early and late asthmatic responses. [O] . S. M. Nasser, G. S. Bell, R. J. Hawksworth, 1994

机译：5-脂氧合酶抑制剂ZD2138对变应原诱导的早期和晚期哮喘反应的影响。
5. Single-dose desloratadine and montelukast and allergen-induced late airway responses [O] . Davis, B. E., Illamperuma, C., Gauvreau, G. M., 2009

机译：单剂量地氯雷他定和孟鲁司特和过敏原诱导的晚期气道反应

Effects of montelukast-desloratadine combination on early and late asthma responses Davis BE, Illamperuma C, Gauvreau GM, et al. Single-dose desloratadine and montelukast and allergen-induced late airway responses. Eur Respir J 2009;33(6):1302-308.

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