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首页> 外文期刊>Expert opinion on pharmacotherapy >Update on antimicrobial agents: new indications of older agents.
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Update on antimicrobial agents: new indications of older agents.

机译：抗菌药物的更新：较旧药物的新适应症。

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摘要

The discovery of newly recognised pathogens and the emergence of antimicrobial resistance have led to the development of new antimicrobial agents or to new indications for older agents. The indications have continued to increase because of new discoveries on the older agents' antimicrobial and non-antimicrobial activities. Macrolides and tetracyclines have received attention for their non-antimicrobial properties and potential use in chronic inflammatory disorders. Doxycycline, minocycline and trimethoprim-sulfamethoxazole regained interest for their activity against methicillin-resistant Staphylococcus aureus, whereas colistin has regained interest for its activity against multiple drug-resistant, Gram-negative pathogens (i.e., Pseudomonas aeruginosa). Despite the recent development of new antimicrobial agents, older and less costly agents maintain an important role today in the treatment of infectious diseases.
机译：新发现的病原体的发现和抗菌素耐药性的出现导致了新的抗菌剂的开发或旧剂的新适应症。由于对老年药物的抗微生物和非抗微生物活性的新发现，适应症持续增加。大环内酯类和四环素类化合物因其非抗菌特性和在慢性炎症性疾病中的潜在用途而受到关注。多西环素，米诺环素和甲氧苄啶-磺胺甲基异恶唑因其对耐甲氧西林金黄色葡萄球菌的活性而重新引起人们的兴趣，而大肠菌素因其对多种耐药性革兰氏阴性病原体（即铜绿假单胞菌）的活性而重新受到关注。尽管最近开发了新的抗微生物剂，但是较老且成本较低的药物如今在传染病的治疗中仍起着重要作用。

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