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Emerging approaches for the treatment of hypertriglyceridemia

机译：新兴的高甘油三酯血症治疗方法

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Hypertriglyceridemia is frequent in diabetic and obese subjects, who are at increased risk for cardiovascular diseases (CVD). Increased triglycerides (TG) are a hallmark of atherogenic dyslipidemia, representing a marker of atherogenic small dense low-density lipoproteins (sdlDL). Importantly, non-fasting/ postprandial TG measurements tend to be emphasized in clinical practice for the prediction of CVD, and TG-lowering agents (primarily fibrates) have a beneficial effect on atherogenic dyslipidemia, reducing TG-rich particles and ultimately lowering the production of sdlDL. The combination of omega-3 fatty acids and statins is also recommended, and widely used in clinical practice for subjects with hypertriglyceridemia. However, a consensus on the optimal clinical use of these pharmacological agents is not fully established yet, and additional large clinical studies are needed. It seems that there is a favorable association between fish consumption and mortality from CVD, but it remains to be confirmed by future trials. Finally, there are a number of novel therapies, such as those targeting microsomal transport protein and its inhibitors, which represent new promising option for treating subjects with hypertriglyceridemia.
机译：高甘油三酯血症在糖尿病和肥胖的受试者中很常见，他们的心血管疾病（CVD）风险增加。甘油三酸酯（TG）升高是动脉粥样硬化血脂异常的标志，代表了动脉粥样硬化的小致密低密度脂蛋白（sdlDL）的标志。重要的是，在临床实践中往往会强调非禁食/餐后TG的测量值，以预测CVD，降TG剂（主要是贝特类药物）对动脉粥样硬化血脂异常具有有益的作用，减少了富含TG的颗粒并最终降低了血脂的产生。 sdlDL。还推荐使用omega-3脂肪酸和他汀类药物的组合，并在高甘油三酯血症患者的临床实践中广泛使用。然而，关于这些药理学药物的最佳临床用途的共识尚未完全建立，因此需要进行其他大型临床研究。鱼类消费与心血管疾病死亡率之间似乎存在良好的联系，但仍有待进一步的试验证实。最后，有许多新颖的疗法，例如针对微粒体转运蛋白及其抑制剂的疗法，代表了治疗高甘油三酯血症受试者的新的有希望的选择。

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