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A review of current anti-HCV treatment regimens and possible future strategies.

机译:回顾当前的抗丙肝病毒治疗方案和可能的未来策略。

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BACKGROUND: Hepatitis C virus (HCV) infection remains a serious health problem worldwide. The current standard treatment of HCV infection is pegylated interferon-alpha plus ribavirin, but this is clearly not sufficiently effective and tolerable. OBJECTIVE: To review current HCV treatment strategies and future options. METHODS: Review of major clinical trials or observational studies when no trial is available. RESULTS/CONCLUSION: Rates of sustained virologic response are widely variable, approximately 40-80%, depending on genotype, and even lower when HIV coinfection occurs. New agents, like small molecules that specifically target the HCV life cycle, may improve response rates; but safety is a concern.
机译:背景:丙型肝炎病毒(HCV)感染仍然是世界范围内的严重健康问题。目前,HCV感染的标准治疗方法是聚乙二醇化干扰素-α加利巴韦林,但这显然不够有效且不能耐受。目的:回顾当前的HCV治疗策略和未来的选择。方法:没有可用的试验时,回顾主要的临床试验或观察性研究。结果/结论:持续的病毒学应答率差异很大,取决于基因型,大约为40-80%,当发生HIV合并感染时,甚至更低。新药,例如专门针对HCV生命周期的小分子,可以提高反应速度;但是安全是一个问题。

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