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首页> 外文期刊>Expert opinion on pharmacotherapy >Single-pill combination of amlodipine and valsartan in the management of hypertension.
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Single-pill combination of amlodipine and valsartan in the management of hypertension.

机译：氨氯地平和缬沙坦的单药组合治疗高血压。

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摘要

Combination therapy is increasingly recommended for selected patients with hypertension to facilitate prompt attainment and maintenance of goal blood pressure (BP). Single-pill combination therapy simplifies treatment and optimizes long-term compliance. Amlodipine, a dihydropyridine calcium antagonist, and valsartan, an angiotensin receptor blocker, are well-established antihypertensive agents with complementary mechanisms of action. This combination lowers BP significantly more than either of its components, and valsartan reduces the incidence of dose-related amlodipine-induced edema. Rigorous clinical trial data have proven the BP-lowering efficacy and high tolerability of the amlodipine/valsartan combination in patients with moderate to severe hypertension as well as other difficult-to-treat populations. Amlodipine/valsartan is indicated as initial therapy in patients who are unlikely to be controlled with a single drug and as second-line therapy in patients not responding adequately to monotherapy.
机译：越来越多地向选定的高血压患者推荐联合治疗，以促进迅速达到和维持目标血压（BP）。单丸组合疗法可简化治疗并优化长期依从性。氨氯地平（一种二氢吡啶类钙拮抗剂）和缬沙坦（一种血管紧张素受体阻滞剂）是公认的具有协同作用机制的降压药。这种组合比任何一种组分都能显着降低BP，并且缬沙坦降低了剂量相关的氨氯地平诱导的水肿的发生率。严格的临床试验数据已经证明，氨氯地平/缬沙坦联合用药在中度至重度高血压患者以及其他难以治疗的人群中具有降低血压的功效和高耐受性。氨氯地平/缬沙坦适用于不太可能用单一药物控制的患者的初始治疗，以及对单药治疗无效的患者的二线治疗。

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