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Advances in the treatment of interstitial cystitis.

机译：间质性膀胱炎的治疗进展。

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Recent years have brought dramatic advances in the clinician's ability to offer effective pharmacotherapy to patients who have interstitial cystitis. Medical treatments have been developed and applied to reduce the interstitial cystitis symptoms of pelvic pain and urinary urgency/frequency, and to address underlying causes of the disorder. In addition, advances in the understanding of the natural history of interstitial cystitis have revealed that it is insidiously progressive and the classical definition--rare, severe and difficult to treat--is in fact the relatively uncommon, advanced stage of a disorder that affects most individuals in a mild-to-moderate and readily treatable form. This recognition has led to the identification of large numbers of previously unsuspected cases of interstitial cystitis, and the successful treatment of many individuals in the early stages of interstitial cystitis when it is far more responsive to therapy. A heparinoid-based multimodal medical regimen can effectively control symptoms and address disease pathophysiology in the majority of cases. Intravesical therapeutic solutions are new and promising adjunctive therapies that can offer immediate symptom relief during symptom flares, and for patients who are just beginning medical therapy.
机译：近年来，临床医生在向间质性膀胱炎患者提供有效药物治疗的能力方面取得了巨大进步。已经开发出医学治疗方法并将其用于减轻盆腔疼痛和尿急/频率的间质性膀胱炎症状，并解决该疾病的根本原因。此外，对间质性膀胱炎自然病程的理解的进步表明，它是隐匿性进行性的，经典定义（罕见，严重且难以治疗）实际上是一种相对罕见的晚期疾病，可影响大多数人处于轻度到中度且易于治疗的状态。这种认识已导致鉴定出大量先前未曾怀疑的间质性膀胱炎病例，并在对间质性膀胱炎的早期阶段对治疗的反应更加敏锐的情况下成功治疗了许多个体。在大多数情况下，基于类肝素的多模式医疗方案可以有效控制症状并解决疾病的病理生理问题。膀胱内治疗解决方案是新颖且有前途的辅助治疗，可在症状发作期间以及刚刚开始药物治疗的患者中立即缓解症状。

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