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Disease-modifying drugs for multiple sclerosis: current and future aspects.

机译:多发性硬化症的疾病改良药物:当前和未来的方面。

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摘要

Multiple sclerosis (MS) is the most common inflammatory demyelinating disorder of the human CNS, affecting an estimated 2.5 million people in the world. Until the 1990s, treatment was mainly symptomatic, but a new era began with the introduction of disease-modifying therapy that seems to alter the natural course of MS. Current drugs include three interferons (IFNs): IFN-beta1a (Avonex intramuscular; Biogen, Cambridge, USA; Rebif subcutaneous; Serono, Geneva, Switzerland), IFN-beta1b (Betaseron subcutaneous; Schering, Berlin, Germany) and glatiramer acetate (Copaxone subcutaneous; Teva, Petach Tikva, Israel). Ongoing research targeting a variety of mechanisms and processes means there is much promise for the future treatment of MS.
机译:多发性硬化症(MS)是人类中枢神经系统最常见的炎症性脱髓鞘疾病,估计全世界有250万人受到影响。直到1990年代,治疗主要是对症治疗,但是新时代开始于疾病改变疗法的引入,该疗法似乎改变了MS的自然病程。目前的药物包括三种干扰素(IFN):IFN-beta1a(肌内Avonex;美国剑桥剑桥的Biogen; Rebif皮下;瑞士日内瓦的Serono),IFN-beta1b(贝他塞隆皮下;德国柏林先灵)和醋酸格拉替雷(Copaxone)皮下; Teva,Petach Tikva,以色列)。针对各种机制和过程的持续研究意味着对MS的未来治疗有很大的希望。

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