...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Experimental Gerontology >Reversal of age-associated thymic atrophy: treatments, delivery, and side effects.
【24h】

Reversal of age-associated thymic atrophy: treatments, delivery, and side effects.

机译：逆转与年龄有关的胸腺萎缩：治疗，分娩和副作用。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Our ability to survive infectious agents depends on making adequate immune responses, but as we get older our thymus atrophies. Production and export of T cells bearing new antigen receptor specificities to the peripheral T cell pool declines and results in shrinkage of the repertoire. Other changes in the peripheral T cell pool include an increase in cells moving closer to their replicative limit. Age related immune dysfunction, evident through the increased susceptibility to infection, follows these changes. Improvement in immune function in the elderly may require us to rejuvenate the immune system starting first with reversing the atrophy seen in the thymus. This has been achieved experimentally with interleukin 7, growth hormone, growth hormone secretagogues, keratinocyte growth factor or through chemical or surgical castration. The widespread use of one or more of these treatments will depend upon their effectiveness, their ease of delivery and the extent of any side effects.
机译：我们生存于传染病中的能力取决于做出足够的免疫反应，但是随着年龄的增长，我们的胸腺萎缩症。携带新抗原受体特异性的T细胞的生产和输出到外周T细胞库的过程减少，并导致库的缩小。外周T细胞池的其他变化包括细胞向其复制极限附近移动的增加。这些变化导致了与年龄相关的免疫功能障碍，这通过对感染的易感性增加而明显。老年人免疫功能的改善可能要求我们首先恢复免疫系统，首先是扭转胸腺中出现的萎缩。这是通过白介素7，生长激素，生长激素促分泌素，角质形成细胞生长因子或通过化学或手术去势而通过实验实现的。这些疗法中的一种或多种的广泛使用将取决于它们的有效性，其递送的容易程度和任何副作用的程度。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号