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首页> 外文期刊>Experimental Gerontology >Lack of association between plasma dehydroepiandrosterone sulfate (DHEA-S) levels and depression in hemodialysis patients: a cross-sectional study.
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Lack of association between plasma dehydroepiandrosterone sulfate (DHEA-S) levels and depression in hemodialysis patients: a cross-sectional study.

机译：血浆透析脱氢表雄酮硫酸盐（DHEA-S）水平与血液透析患者抑郁之间缺乏关联：一项横断面研究。

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OBJECTIVE: Depression is common in hemodialysis patients. Reduced DHEA-S levels have been shown to be associated with depression in general population. Abnormalities in hormone production and metabolism are found in hemodialysis patients. However, the association between DHEA-S levels and depression in hemodialysis patients has not been established. METHOD: We conducted a cross-sectional study, in which 80 patients under regular hemodialysis were studied, and their serum DHEA-S levels were analyzed. RESULTS: The prevalence of depression in our studied hemodialysis population is 37.5% (30/80). The DHEA-S level was 1138.1+/-1216.9 ng/mL in male patients and 502.1+/-389.4 ng/mL in female patients. The levels were not significantly different between patients with or without depression (910.8+/-1127.1 ng/mL vs. 769.3+/-848.3 ng/mL, P=0.533). As compared to the non-depressed patients, the depressed patients were more likely to be male, with lower body mass index, consuming more alcohol, and with more co-morbidity. The prevalence of depression was not associated with age, educational background, smoking, duration of dialysis, hemoglobin, albumin, CRP, ferritin, and urea clearance (Kt/V and URR). The serum DHEA-S levels exhibited significant and independent associations with age, gender, diabetes mellitus, and the levels of serum albumin. CONCLUSION: The study suggested a lack of association between plasma DHEA-S levels and depression in hemodialysis patients.
机译：目的：血液透析患者常见抑郁症。 DHEA-S水平降低与普通人群的抑郁症有关。在血液透析患者中​​发现了激素产生和代谢异常。但是，尚未确定血液透析患者中​​DHEA-S水平与抑郁之间的关联。方法：我们进行了一项横断面研究，对80例定期进行血液透析的患者进行了研究，并对他们的血清DHEA-S水平进行了分析。结果：在我们研究的血液透析人群中，抑郁症的患病率为37.5％（30/80）。男性患者的DHEA-S水平为1138.1 +/- 1216.9 ng / mL，女性患者为502.1 +/- 389.4 ng / mL。患有或不患有抑郁症的患者之间的水平无显着差异（910.8 +/- 1127.1 ng / mL与769.3 +/- 848.3 ng / mL，P = 0.533）。与非抑郁症患者相比，抑郁症患者更可能是男性，体重指数较低，饮酒较多且合并症更多。抑郁症的患病率与年龄，学历，吸烟，透析时间，血红蛋白，白蛋白，CRP，铁蛋白和尿素清除率（Kt / V和URR）无关。血清DHEA-S水平与年龄，性别，糖尿病和血清白蛋白水平呈显着且独立的关联。结论：该研究提示血液透析患者血浆DHEA-S水平与抑郁症之间缺乏关联。

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