Targeting the unfolded protein response for disease intervention

Rivas Alexis; Vidal Rene Luis; Hetz Claudio

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Targeting the unfolded protein response for disease intervention

机译：针对展开的蛋白质反应进行疾病干预

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Introduction: The accumulation of misfolded proteins in the endoplasmic reticulum (ER) generates a stress condition that engages the unfolded protein response (UPR). The UPR is an adaptive reaction that aims to reestablish ER proteostasis by recovering the folding capacity of the cell. However, chronic ER stress results in apoptosis.

机译：简介：错误折叠的蛋白质在内质网（ER）中的积累会产生与未折叠的蛋白质应答（UPR）结合的应激状态。 UPR是一种适应性反应，旨在通过恢复细胞的折叠能力来重建ER蛋白变性。但是，慢性内质网应激会导致细胞凋亡。

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《Expert opinion on therapeutic targets》 |2015年第9期|共16页
作者
Rivas Alexis; Vidal Rene Luis; Hetz Claudio;
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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
endoplasmic reticulum stress signaling.; pharmacological modulator; protein misfolding disorders; unfolded protein response;

机译：内质网应激信号;药理调节剂;蛋白质错误折叠障碍;未折叠的蛋白质反应;

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专利

1. Pharmacological targeting of the unfolded protein response for disease intervention [J] . Hetz Claudio, Axten Jeffrey M., Patterson John B. Nature chemical biology . 2019,第8期

机译：疾病干预展开蛋白质反应的药理靶向
2. Targeting unfolded protein response signaling pathways to ameliorate protein misfolding diseases [J] . Ryno L.M., Wiseman R.L., Kelly J.W. Current opinion in chemical biology . 2013,第3期

机译：靶向未折叠的蛋白质反应信号传导途径，以改善蛋白质错误折叠疾病
3. Protein quality control-linking the unfolded protein response to disease Conference on 'From Unfolded Proteins in the Endoplasmic Reticulum to Disease' [J] . Cyr DM, Hebert DN EMBO reports . 2009,第11期

机译：蛋白质质量控制，将未折叠的蛋白质对疾病的反应联系起来关于“从内质网中的未折叠蛋白质到疾病”的会议
4. Unfolded protein response to autophagy as a promising druggable target for anticancer therapy [C] . Dong Hoon Suh, Mi-Kyung Kim, Hee Seung Kim, International Conference on Nutrition and Physical Activity in Aging, Obesity, and Cancer . 2012

机译：展开蛋白质反应自噬作为抗癌治疗的有前途的可用毒性目标
5. RNA Terminus Chemistry Potentiates Decay Events That Target HAC1 mRNA During the Unfolded Protein Response [D] . Cherry, Patrick. 2019

机译：RNA末端化学增强衰变在展开蛋白质反应期间靶向HAC1 mRNA的衰变事件
6. Targeting unfolded protein response signaling pathways to ameliorate protein misfolding diseases [O] . Lisa M Ryno, R Luke Wiseman, Jeffery W Kelly -1

机译：靶向未折叠的蛋白质反应信号传导途径以改善蛋白质错误折叠疾病
7. Publisher Correction: Pharmacological targeting of the unfolded protein response for disease intervention [O] . Claudio Hetz, Jeffrey M. Axten, John B. Patterson 2019

机译：出版商校正：疾病干预展开蛋白质反应的药理靶向

Targeting the unfolded protein response for disease intervention

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