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首页> 外文期刊>Expert opinion on therapeutic targets >Adenosine pathway and cancer: Where do we go from here?
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Adenosine pathway and cancer: Where do we go from here?

机译：腺苷途径与癌症：我们从这里去哪里？

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Increasing evidence supports the occurrence of an intriguing link between tumor onset and development with the microenvironment in which cancer cells are embedded. In this context, a critical role of CD73, in calibrating the duration, magnitude and composition of adenosine signaling in cancer development and progression, has been identified. Adenosine levels are increased in cancer tissues as the result of genetic alterations that occur during tumor progression. Indeed, a rearrangement of the adenosine metabolic machinery has been described within the neoplastic milieu with the aim of amplifying adenosine generation, thereby creating an immune tolerant microenvironment suitable for tumor onset and development. At the same time, adenosine, through the engagement of receptors expressed on neoplastic cells, finely tunes the growth and dissemination of tumor mass, thus interfering with cancer proliferation, apoptosis and metastasis. Based on current knowledge, an improved understanding of how and to what extent adenosine participates to the molecular mechanisms underlying cancer development and diffusion will pave the way toward new therapeutic advances. The discovery and development of drugs targeted on this system might lead to substantial improvements in the clinical management of various cancers.
机译：越来越多的证据支持在肿瘤发作和发展与其中嵌有癌细胞的微环境之间产生令人着迷的联系。在这种情况下，已经确定了CD73在校准腺苷信号传导的持续时间，幅度和组成方面在癌症发展和进程中的关键作用。由于肿瘤进展过程中发生的基因改变，癌症组织中的腺苷水平升高。实际上，已经在赘生物环境中描述了腺苷代谢机制的重排，其目的是扩增腺苷的产生，从而产生适合于肿瘤发作和发展的免疫耐受的微环境。同时，腺苷通过在肿瘤细胞上表达的受体的参与，微调肿瘤块的生长和扩散，从而干扰癌症的增殖，凋亡和转移。根据目前的知识，对腺苷如何以及在何种程度上参与癌症发展和扩散的分子机制的更好理解将为新的治疗方法铺平道路。针对该系统的药物的发现和开发可能会导致各种癌症的临床管理得到实质性改善。

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