The potential for phospholipase D as a new therapeutic target.

Huang P; Frohman MA

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The potential for phospholipase D as a new therapeutic target.

机译：磷脂酶D作为新治疗靶标的潜力。

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Mammalian phospholipase D (PLD), a signal transduction-activated enzyme, hydrolyzes phosphatidylcholine to generate the lipid second messenger phosphatidic acid (PA) and choline. Genetic and pharmacological methods have implicated PLD and its product PA in a wide variety of cellular processes including vesicle trafficking, receptor signaling, cell proliferation and survival. Dysregulation of these cell biologic processes occurs in a diverse range of illnesses including cancer. This review summarizes PLD regulation and function and highlights its potential as a therapeutic target in disease settings.

机译：哺乳动物磷脂酶D（PLD）是一种信号转导激活的酶，可水解磷脂酰胆碱以生成脂质第二信使磷脂酸（PA）和胆碱。遗传和药理学方法已将PLD及其产物PA牵涉到多种细胞过程中，包括囊泡运输，受体信号传导，细胞增殖和存活。这些细胞生物学过程的失调发生在包括癌症在内的多种疾病中。这篇综述总结了PLD的调节和功能，并着重指出了其在疾病环境中作为治疗靶标的潜力。

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《Expert opinion on therapeutic targets》 |2007年第5期|共10页
作者
Huang P; Frohman MA;
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正文语种 eng
中图分类药学;
关键词
Therapeutic; 1-dodecylpyridoxal; Phospholipase D; Anterior-Posterior; activate; 磷脂酶D;

机译：Therapeutic;1-dodecylpyridoxal;Phospholipase D;Anterior-Posterior;activate;磷脂酶D;

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1. Lipoprotein-associated phospholipase A2: a cardiovascular risk predictor and a potential therapeutic target. [J] . Ali M, Madjid M Future cardiology . 2009,第2期

机译：脂蛋白相关的磷脂酶A2：心血管疾病的风险预测因子和潜在的治疗靶标。
2. Lipoprotein-associated phospholipase A2: a new biomarker for cardiovascular risk assessment and potential therapeutic target. [J] . Carlquist JF, Muhlestein JB, Anderson JL Expert Review of Molecular Diagnostics . 2007,第5期

机译：脂蛋白相关的磷脂酶A2：心血管风险评估和潜在治疗目标的新生物标志物。
3. Role of lipoprotein-associated phospholipase A2 in atherosclerosis and its potential as a therapeutic target. [J] . Macphee CH, Nelson J, Zalewski A Current opinion in pharmacology . 2006,第2期

机译：脂蛋白相关磷脂酶A2在动脉粥样硬化中的作用及其作为治疗靶标的潜力。
4. DEGRADATION OF POLYMER COVERED LIPOSOMES BY PHOSPHOLIPASE A2: A POTENTIAL MECHANISM FOR LOCALIZED DRUG DELIVERY [C] . J. Davidsen, Rene Holm, T. L. Andresen, Proceedings of the 29th Annual Meeting of the Controlled Release Society . 2002

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5. Ca2+ Signaling Involved in Pancreatic Stellate Cell Proliferation and Identification of a Potential Therapeutic Target. [D] . Fricke, Alexander Ford. 2016

机译：Ca 2 +信号参与胰腺星状细胞增殖和潜在治疗靶标的鉴定。
6. Induction of cell death by stimulation of protein kinase C in human epithelial cells expressing a mutant ras oncogene: a potential therapeutic target. [O] . C. A. Hall-Jackson, T. Jones, N. G. Eccles, 1998

机译：在表达突变型ras癌基因的人上皮细胞中刺激蛋白激酶C诱导细胞死亡：潜在的治疗靶点。
7. Circulating miR-223 in Oral Cancer: Its Potential as a Novel Diagnostic Biomarker and Therapeutic Target. [O] . Hirohiko Tachibana, Ri Sho, Yuji Takeda, 2016

机译：在口腔癌中循环miR-223：其作为新型诊断生物标志物和治疗靶标的潜力。
8. Low Voltage Activated Calcium Channels - Their Role in HER2 Driven Breast Cancer and Potential as a New Therapeutic Target. [R] . Dziegielewski, J. 2016

机译：低电压活化钙通道 - 它们在HER2驱动的乳腺癌中的作用和作为新治疗靶点的潜力。

The potential for phospholipase D as a new therapeutic target.

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