...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Experimental Gerontology >Aging: a revisited theory based on free radicals generated by NOX family NADPH oxidases.
【24h】

Aging: a revisited theory based on free radicals generated by NOX family NADPH oxidases.

机译：老化：基于NOX家族NADPH氧化酶产生的自由基的再研究理论。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Reactive oxygen species (ROS), often also referred to as free radicals, play an important role in aging. It is widely assumed that mitochondria are the predominant source of ROS relevant for the aging process. In this hypothesis article, we suggest that the role of ROS generated by NOX family NADPH oxidases has been largely overlooked in aging theories. NOX NADPH oxidases form a seven member gene family and are high level ROS-generating enzymes. As opposed to mitochondria, which generate ROS as a byproduct of their metabolism, NOX enzymes are professional ROS generators. From an experimental point of view, there is now abundant evidence for the involvement of NOX enzymes in age-associated diseases. The role of NOX enzymes in the aging process itself and their relative contribution as compared to mitochondria needs further investigations.
机译：活性氧（ROS），通常也称为自由基，在衰老中起重要作用。普遍认为线粒体是与衰老过程相关的ROS的主要来源。在此假设文章中，我们建议由NOX家族NADPH氧化酶产生的ROS在衰老理论中已被大大忽略。 NOX NADPH氧化酶形成七个成员基因家族，是高水平的ROS产生酶。与线粒体相反，线粒体在其代谢的副产物中产生ROS，而NOX酶是专业的ROS生成器。从实验的角度来看，现在有大量证据表明NOX酶参与了与年龄有关的疾病。与线粒体相比，NOX酶在衰老过程中的作用及其相对作用还需要进一步研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号