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首页> 外文期刊>Experimental Gerontology >The relationship between age-related hearing loss and synaptic changes in the hippocampus of C57BL/6J mice.
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The relationship between age-related hearing loss and synaptic changes in the hippocampus of C57BL/6J mice.

机译：C57BL / 6J小鼠的年龄相关性听力损失与海马突触变化之间的关系。

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摘要

To explore the relationship between age-related hearing loss (presbycusis) and synaptic degeneration in the hippocampal CA3 region of C57BL/6J mice, we investigated both cognitive performance and synaptic changes within the hippocampus of C57BL/6J mice from three age groups of 6-8, 24-26, and 42-44 weeks; CBA/CaJ mice served as controls. The auditory brainstem response was used as a measure of hearing threshold, and cognitive behavior was evaluated using the Morris water maze. The ultrastructure of synapses was observed with transmission electron microscopy, and the quantity and distribution of the synaptic markers synaptophysin and PSD-95 were observed with immunohistochemistry. The hearing threshold of C57BL/6J mice was significantly higher at 24-26 weeks than at 6-8 weeks, and hearing loss was profound at 42-44 weeks. This was accompanied by progressive degeneration of synapses within the auditory cortex. In contrast, the hearing threshold of CBA/CaJ mice was relatively unchanged at 24-26 weeks of age, and these mice developed only mild hearing loss at 42-44 weeks of age. Interestingly, C57BL/6J, but not CBA/CaJ mice clearly exhibited both decreased performance in the Morris water maze and degeneration of synapses within the hippocampus. We therefore conclude that age-related hearing loss is accompanied by the degeneration of synapses in the hippocampal CA3 region of C57BL/6J mice.
机译：为了探讨C57BL / 6J小鼠海马CA3区与年龄相关的听力下降（耳聋）与突触变性之间的关系，我们调查了6- 8、24-26和42-44周; CBA / CaJ小鼠用作对照。听觉脑干反应用作听力阈值的量度，并使用莫里斯水迷宫评估认知行为。透射电镜观察突触的超微结构，免疫组化观察突触标记物突触素和PSD-95的数量和分布。 C57BL / 6J小鼠的听力阈值在24-26周时显着高于6-8周，并且在42-44周时听力损失严重。这伴随着听觉皮层内突触的逐渐退化。相反，CBA / CaJ小鼠的听力阈值在24-26周龄时相对不变，并且这些小鼠在42-44周龄时仅出现轻度听力下降。有趣的是，C57BL / 6J小鼠（但不是CBA / CaJ小鼠）清楚地显示出在Morris水迷宫中的性能下降和海马内突触的退化。因此，我们得出结论，与年龄有关的听力损失伴随有C57BL / 6J小鼠海马CA3区突触的变性。

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