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首页> 外文期刊>Eye & contact lens >Amiodarone-induced keratopathy: full-thickness corneal involvement.
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Amiodarone-induced keratopathy: full-thickness corneal involvement.

机译：胺碘酮引起的角膜病变：全层角膜受累。

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摘要

PURPOSE: To report a case of amiodarone-induced keratopathy involving the entire cornea, including the endothelium. METHODS: Clinical case description and documentation with confocal laser scanning microscopy using the Heidelberg Retinal Tomography II (HRT II). RESULTS: A 65 year-old man with a history of blurred vision and seeing halos around lights had been treated with amiodarone for 6 years. Best-corrected visual acuity was 20/25 in each eye. Slitlamp examination of both eyes showed a bilateral, symmetric, whorllike pattern of brown deposits in the inferocentral corneal epithelium. Diffuse and fine deposits resembling keratic precipitates in the central part of the endothelial face were also detected. Examination of the lens, optic nerve, and fundus in each eye did not show any abnormalities that could be attributed to the amiodarone therapy. Severe endothelial deposition was documented with the confocal laser scanning microscope of the HRT II. CONCLUSIONS: Amiodarone-induced keratopathy with confluent and diffuse endothelial deposition is rare, and it may be indicative of a more severe toxicity associated with amiodarone.
机译：目的：报告一例胺碘酮引起的角膜病变，涉及整个角膜，包括内皮。方法：使用Heidelberg视网膜断层扫描II（HRT II）通过共聚焦激光扫描显微镜对临床病例进行描述和记录。结果：一位65岁的男人有视力模糊的历史，并在灯光下看到光晕，已接受胺碘酮治疗6年。每只眼睛的最佳矫正视力为20/25。两只眼睛的裂隙灯检查显示在中央下角膜上皮中有一个双侧的，对称的，螺旋状的褐色沉积物。还检测到了内皮表面中央部分的类似于角质沉淀物的弥散性细小沉积物。对每只眼睛的晶状体，视神经和眼底进行检查均未发现任何可归因于胺碘酮治疗的异常。用HRT II的共聚焦激光扫描显微镜记录了严重的内皮沉积。结论：胺碘酮引起的角膜病变伴有内皮细胞弥漫性扩散，这很罕见，这可能表明胺碘酮具有更严重的毒性。

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