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首页> 外文期刊>Eye & contact lens >Impact of contact lens materials on multipurpose contact lens solution disinfection activity against fusarium solani
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Impact of contact lens materials on multipurpose contact lens solution disinfection activity against fusarium solani

机译：隐形眼镜材料对多功能隐形眼镜溶液对枯萎镰刀菌消毒活性的影响

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OBJECTIVE:: To investigate the effects of eight different soft contact lenses on disinfection efficacy of a multipurpose solution (MPS) containing polyhexamethylene biguanide (PHMB) against Fusarium solani. METHODS:: Six silicone hydrogel lenses (galyfilcon A, senofilcon A, comfilcon A, enfilcon A, balafilcon A, and lotrifilcon B) and two conventional hydrogel lenses (polymacon and etafilcon A) were placed in polypropylene lens cases filled with MPS containing 0.0001% PHMB and soaked for 6, 12, 24, 72, and 168 hours. After each interval, depleted MPS from lens cases were removed and assayed for activity against F. solani according to International Organization for Standardization (ISO) 14729 stand-alone procedure. A portion was aliquoted for chemical analysis. RESULTS:: Soaking etafilcon A, balafilcon A, and polymacon lenses for 6 hours reduced the concentration of PHMB in MPS by more than half the stated labeled concentration, with concentrations below the limit of detection for etafilcon A-depleted and balafilcon A-depleted solutions after 12 and 72 hours of soaking, respectively. Except for comfilcon A-depleted solutions, all others failed to consistently obtain one log reduction of F. solani. The solutions soaked with etafilcon A, balafilcon A, and polymacon lenses for 24 hours or more lost all or almost all fungicidal activity against F. solani. CONCLUSIONS:: Over time, the disinfectant uptake by some lenses can significantly reduce the PHMB concentration and the fungicidal activity of the MPS against F. solani. Current ISO methodology does not address the reduction in microbiocidal efficacy when lenses are soaked in MPS. The ISO committee should consider adding "soaking experiments" to quantify the effect that contact lens materials have on the performance of MPSs.
机译：目的：研究八种不同的软性隐形眼镜对含有聚六亚甲基双胍（PHMB）的多用途溶液（MPS）对茄枯萎病菌的消毒效果。方法：将六只硅酮水凝胶镜片（galyfilcon A，senofilcon A，comfilcon A，enfilcon A，balafilcon A和lotrifilcon B）和两支常规水凝胶镜片（polymacon和etafilcon A）放在装有0.0001％MPS的聚丙烯眼镜盒中。将PHMB浸泡6、12、24、72和168小时。在每个间隔之后，根据国际标准化组织（ISO）14729独立程序，从镜盒中取出耗尽的MPS并分析其对茄形鳞孢菌的活性。等分一部分用于化学分析。结果：将etafilcon A，balafilcon A和polymacon镜片浸泡6小时，可使MPS中的PHMB浓度降低一半，达到标示浓度的一半，且浓度低于耗尽etafilcon A和balafilcon A的溶液的检测极限分别浸泡12和72小时后。除了使用comfilcon A的解决方案外，所有其他解决方案均未能始终如一地减少sol。F. solani。用etafilcon A，balafilcon A和polymacon镜片浸泡24小时或更长时间的溶液失去了全部或几乎所有对茄形镰刀菌的杀真菌活性。结论：随着时间的流逝，某些镜片吸收的消毒剂可以显着降低PHMB浓度和MPS对茄形镰刀菌的杀真菌活性。当前的ISO方法无法解决将镜片浸泡在MPS中时杀微生物功效降低的问题。 ISO委员会应考虑添加“浸泡实验”，以量化隐形眼镜材料对MPS性能的影响。

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