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首页> 外文期刊>Eye & contact lens >The impact of punctal occlusion on soft contact lens wearing comfort and the tear film.
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The impact of punctal occlusion on soft contact lens wearing comfort and the tear film.

机译：泪点闭塞对软性隐形眼镜佩戴舒适度和泪膜的影响。

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OBJECTIVES: The purpose of this report is to describe the impact of punctal occlusion in symptomatic dry eye contact lens wearers and the relation between subjective and objective outcomes. METHODS: This study was a randomized, controlled, double-masked, single center clinical trial. A previously described dry-eye questionnaire was used to determine subject eligibility. Tear interferometry was performed to evaluate prelens tear film thickness, contact lens center thickness, and postlens tear film thickness. Each subject was randomly assigned to receive the punctal plugs or a sham procedure. At the outcome examination, the subject completed the dry-eye questionnaire and answered one question rating the efficacy of the punctal plug treatment in addition to undergoing tear interferometry using an identical protocol as the first visit. RESULTS: Nineteen subjects completed both visits of this study. There was a significant improvement in the dry-eye questionnaire scores from baseline to the outcome visit for both the plug (Z = -2.52, P=0.01) and sham groups (Z = -2.93, P=0.003). A significant increase in prelens tear film thickness occurred within the sham group from baseline to the outcome visit (Z = -1.96, P=0.05), but not for the punctal plug group. No other layers measured by interferometry were shown to change significantly for either group. CONCLUSIONS: Results comparing the sham and plug groups were not significantly different from each other with regards to the questionnaire score and treatment benefit assessment, indicating either the treatment effect was not detected, although present, or punctal occlusion had no treatment effect at all.
机译：目的：本报告的目的是描述点状闭塞对有症状干眼隐形眼镜佩戴者的影响以及主观和客观结果之间的关系。方法：本研究是一项随机，对照，双掩蔽，单中心临床试验。使用先前描述的干眼问卷来确定受试者的资格。进行泪液干涉术以评估前镜片的泪膜厚度，隐形眼镜中心厚度和后镜片的泪膜厚度。每个受试者被随机分配接受泪点塞或假手术。在结局检查中，该受试者完成了干眼问卷并回答了一个评估泪点塞治疗效果的问题，除了使用与第一次就诊相同的方案进行泪液干涉术外。结果：19名受试者完成了本研究的两次访问。从基线到随访结果，即插即用组（Z = -2.52，P = 0.01）和假组（Z = -2.93，P = 0.003）的干眼问卷得分都有显着改善。从基线到结果访视，假手术组内前屈泪膜厚度显着增加（Z = -1.96，P = 0.05），但泪点塞组则没有。两组均未显示通过干涉测量法测得的其他层有明显变化。结论：假手术组和栓塞组的比较结果在问卷评分和治疗效益评估方面无显着差异，表明虽然存在，但仍未检测到治疗效果，或者泪点闭塞完全没有治疗效果。

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