A woman in her 50s underwent an EGD in our unit to evaluate symptoms of gastroesophageal reflux. A small, mucosal lesion was seen in mid-esophagus, with a characteristic verrucous appearance reminiscent of papilloma-tous warts seen on the skin (A). Biopsy showed well-developed squamous hyperplasia without evidence of carcinoma, and the decision was made to proceed with endoscopic resection. A submucosal saline solution injection was performed to lift the lesion and to ensure complete resection, after which snare polypectomy was done. All remaining satellite foci were ablated with an argon plasma coagulator. Human papilloma virus DNA was not detected in the resection specimen.
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