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首页> 外文期刊>European journal of ophthalmology >Optical coherence tomography in neovascular age related macular degeneration compared to fluorescein angiography and visual acuity.
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Optical coherence tomography in neovascular age related macular degeneration compared to fluorescein angiography and visual acuity.

机译：与荧光素血管造影和视敏度相比，新血管性年龄相关性黄斑变性的光学相干断层扫描。

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PURPOSE: To assess the sensitivity and specificity of optical coherence tomography (OCT) for monitoring patients with choroidal neovascularization (CNV) after photodynamic therapy (PDT) in comparison to fluorescein angiography (FA). METHODS: Prospective study of 14 patients with CNV secondary to age-related macular degeneration receiving PDT. Best-corrected visual acuity (BCVA), fluorescein angiography, and OCT (Zeiss Stratus OCT3) were performed before and at 2, 6, 12, and 24 weeks after treatment. FA images were assessed for leakage and presence of subretinal or intraretinal fluid was assessed on OCT images. Retinal thickness was measured automatically. OCT sensitivity and specificity levels for detecting leaking CNV were calculated. Retinal thickness was correlated with visual acuity. RESULTS: Mean follow-up time was 14.1 weeks. Sixty-one OCT/FA examinations were analyzed. Thirty-one examinations presented leakage (51%). OCT showed intraretinal fluid in 46 (75%) and subretinal fluid in 30 cases (49%). In 49 cases (80%), either intraretinal or subretinal fluid was present. Sensitivity for detecting intraretinal fluid in OCT was 90% (specificity 40%) and 71% (specificity 73%) for subretinal fluid. Combined sensitivity for intraretinal or subretinal fluid was 97% (specificity 37%). Increased central foveal thickness correlated with decreased BCVA. Correlations were significant (p<0.05). CONCLUSIONS: OCT showed good sensitivity in detecting active CNV. Specificity was only moderate. Central foveal thickness correlated negatively with visual acuity. Owing to different aspects of active CNV shown by FA and OCT, OCT should be combined with other examinations, and may not substitute FA for indication/reindication of PDT but can be a valuable addition in difficult cases.
机译：目的：评估光学相干断层扫描（OCT）与荧光素血管造影（FA）相比，在监测光动力治疗（PDT）后脉络膜新生血管（CNV）患者的敏感性和特异性。方法：前瞻性研究14例年龄相关性黄斑变性继发的CNV患者接受PDT。最佳矫正视力（BCVA），荧光素血管造影术和OCT（Zeiss Stratus OCT3）在治疗前和治疗后2、6、12和24周进行。对FA图像进行渗漏评估，并在OCT图像上评估视网膜下或视网膜内液的存在。自动测量视网膜厚度。计算了OCT敏感性和特异性水平，以检测泄漏的CNV。视网膜厚度与视力相关。结果：平均随访时间为14.1周。分析了61个OCT / FA检查。 31项检查显示渗漏（51％）。 OCT显示视网膜内积液46例（75％），视网膜下积液30例（49％）。在49例（80％）中，存在视网膜内或视网膜下积液。在OCT中检测视网膜内液的敏感性对于视网膜下液为90％（特异性40％）和71％（特异性73％）。视网膜内或视网膜下液的联合敏感性为97％（特异性37％）。中央凹厚度增加与BCVA降低相关。相关性显着（p <0.05）。结论：OCT在检测活动性CNV方面显示出良好的灵敏度。特异性仅为中等。中央凹的厚度与视力呈负相关。由于FA和OCT显示的活动CNV的不同方面，OCT应该与其他检查结合使用，并且不能代替FA来代替PDT的指示/再指示，但是在困难的情况下可以作为有价值的补充。

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