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首页> 外文期刊>General and comparative endocrinology >Endocrine regulation of ion transport in the avian lower intestine.
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Endocrine regulation of ion transport in the avian lower intestine.

机译：内分泌调节禽小肠中离子的迁移。

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摘要

The lower intestine (colon and coprodeum) of the domestic fowl maintains a very active, transporting epithelium, with a microvillus brush border, columnar epithelial cells, and a variety of transport systems. The colon of normal or high salt-acclimated hens expresses sodium-linked glucose and amino acid cotransporters, while the coprodeum is relatively inactive. Following acclimation to low salt diets, however, both colon and coprodeum shift to a pattern of high expression of electrogenic sodium channels, and the colonic cotransporter activity is simultaneously downregulated. These changes in the transport patterns seem to be regulated, at least in part, by aldosterone. Our recent work with this tissue has focused on whether aldosterone alone can account for the low salt pattern of transport. Other work has looked at the changes in morphology and in proportions of cell types that occur during chronic acclimation to high or low salt diets, and on a cAMP-activated chloride secretion pathway. Recent findings suggesting effects of other hormones on lower intestinal transport are also presented.
机译：家禽的下肠道（结肠和副前肠）保持着非常活跃的运输上皮，带有微绒毛刷状缘，柱状上皮细胞和多种运输系统。正常或高盐适应水平的母鸡的结肠表达与钠连接的葡萄糖和氨基酸共转运蛋白，而副蛋白相对没有活性。但是，在适应低盐饮食之后，结肠和副蛋白都转变为电钠通道的高表达模式，并且结肠的共转运蛋白活性同时被下调。似乎至少部分地由醛固酮调节运输模式的这些变化。我们最近对这种组织的研究集中在仅醛固酮是否可以解释低盐运输模式上。其他工作研究了在长期适应高盐或低盐饮食以及cAMP激活的氯离子分泌途径中发生的形态变化和细胞类型比例的变化。最近的研究结果表明，其他激素对下肠道的运输也有影响。

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