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首页> 外文期刊>General and comparative endocrinology >Chronic kisspeptin administration stimulated gonadal development in pre-pubertal male yellowtail kingfish (Seriola lalandi; Perciformes) during the breeding and non-breeding season
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Chronic kisspeptin administration stimulated gonadal development in pre-pubertal male yellowtail kingfish (Seriola lalandi; Perciformes) during the breeding and non-breeding season

机译：在繁殖和非繁殖季节，长期使用吻肽酶刺激青春期前雄性黄尾tail（Seriola lalandi; Perciformes）的性腺发育。

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摘要

The kisspeptin system is now accepted as a key regulator of vertebrate reproductive function, particularly the onset of puberty. In teleosts, the stimulatory effect of exogenous kisspeptins has been demonstrated mainly at the hypothalamic and pituitary levels of the reproductive axis, with very limited information pertaining to gonadal response. We determined the effect of chronic peripheral administration of the conserved kisspeptin decapeptides (YNLNSFGLRY or Kiss1-10; and FNFNPFGLRF or Kiss2-10) on gonadal development of pre-pubertal yellowtail kingfish (Seriola lalandi), a Perciform teleost, during the breeding and non-breeding season. We utilized slow-release implants to chronically deliver the synthesized peptides, which were based on the yellowtail kingfish kiss1 and kiss2 cDNA sequences that we isolated. The expression level of kiss2r and gnrh1 in the brain or hypothalamus did not vary between treated and control groups. Pituitary expression of fshβ and lhβ was upregulated only with Kiss1-10 treatment regardless of the season. Based on histological evidence, gonadal development was stimulated in male fish with either Kiss1-10 or Kiss2-10, with Kiss2-10 being more effective during the non-breeding period. Overall, our results suggest that kisspeptins modulate the early gonadal development of male yellowtail kingfish, however that may vary with the breeding season.
机译：现在，kisepteptin系统被认为是脊椎动物生殖功能（尤其是青春期发作）的关键调节器。在硬骨鱼中，主要在生殖轴的下丘脑和垂体水平上证实了外源性亲吻肽素的刺激作用，有关性腺反应的信息非常有限。我们确定了在育种期间和非繁殖期长期施用保守的kisepteptin十肽（YNLNSFGLRY或Kiss1-10和FNFNPFGLRF或Kiss2-10）对早熟黄尾tail（Seriola lalandi）的性腺发育的影响。 -繁殖季节。我们利用缓释植入物来长期递送合成的肽，这些肽是基于我们分离出的黄尾翠鸟kiss1和kiss2 cDNA序列。在治疗组和对照组之间，大脑或下丘脑中kiss2r和gnrh1的表达水平没有变化。不论季节如何，仅用Kiss1-10处理均可上调fshβ和lhβ的垂体表达。根据组织学证据，用Kiss1-10或Kiss2-10刺激雄鱼的性腺发育，而Kiss2-10在非繁殖期更有效。总体而言，我们的结果表明，kisepteptin可以调节雄性yellow鱼翠鸟的早期性腺发育，但是可能随繁殖季节而变化。

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