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首页> 外文期刊>Evidence-based complementary and alternative medicine: eCAM >Antimicrobial Activity of Lippia Species from the Brazilian Semiarid Region Traditionally Used as Antiseptic and Anti-Infective Agents
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Antimicrobial Activity of Lippia Species from the Brazilian Semiarid Region Traditionally Used as Antiseptic and Anti-Infective Agents

机译：传统上用作防腐剂和抗感染剂的巴西半干旱地区的Lippia物种的抗菌活性

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摘要

Lippia origanoides Kunth, Lippia alnifolia Schauer, and Lippia thymoides Martius and Schauer are shrubs used in the traditional Brazilian medicine as antiseptics, as well as in the treatment of infectious diseases. This study was designed to investigate the antibacterial and antifungal activities of the methanolic extracts of these species, as new potential sources of antimicrobial drugs. The antimicrobial activity of methanolic extracts was investigated against resistant yeasts and bacteria by agar disk diffusion. Then, the MIC determination of the most active species and its fractions in hexane, dichloromethane, ethyl acetate, and water was performed. By the agar diffusion assay, all species were active against at least two microorganisms, giving evidence to support their use in the popular medicine. L. origanoides leaves exhibited the widest antimicrobial action, inhibiting the growth of two Gram-positive bacteria and two yeasts; this activity was also confirmed by the MIC evaluation. The fractionation of L. origanoides crude extracts improved the activity in spectrum and intensity. The results obtained in this study indicate that L. origanoides may be a promising alternative in the treatment of bacterial and fungal infections and in the seeking of new antimicrobial drugs.
机译：紫薇（Lippia origanoides Kunth），紫花苜蓿（Lippia alnifolia Schauer）和百里香（Lippia thymoides）Martius和Schauer是灌木，在巴西传统医学中用作防腐剂，并用于治疗传染病。这项研究旨在调查这些物种的甲醇提取物的抗菌和抗真菌活性，以此作为抗菌药物的新潜在来源。通过琼脂圆盘扩散研究了甲醇提取物对耐药酵母和细菌的抗菌活性。然后，用MIC测定在己烷，二氯甲烷，乙酸乙酯和水中的活性最高的物质及其馏分。通过琼脂扩散分析，所有物种均具有针对至少两种微生物的活性，从而提供了证据支持它们在流行医学中的使用。牛至的叶展现出最广泛的抗菌作用，抑制了两种革兰氏阳性细菌和两种酵母的生长。 MIC评估也证实了这一活动。 Origanoides粗提物粗提物的分馏提高了光谱和强度的活性。在这项研究中获得的结果表明，牛至的L. origanoides在治疗细菌和真菌感染以及寻找新的抗菌药物方面可能是一个有前途的替代方法。

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