• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Evidence-based complementary and alternative medicine: eCAM >Xiao-Ai-Ping, a TCM Injection, Enhances the Antigrowth Effects of Cisplatin on Lewis Lung Cancer Cells through Promoting the Infiltration and Function of CD8~+ T Lymphocytes
【24h】

Xiao-Ai-Ping, a TCM Injection, Enhances the Antigrowth Effects of Cisplatin on Lewis Lung Cancer Cells through Promoting the Infiltration and Function of CD8~+ T Lymphocytes

机译：中药注射液小爱平通过促进CD8〜+ T淋巴细胞的浸润和功能增强顺铂对Lewis肺癌细胞的抗生长作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objectives. To investigate how Xiao-Ai-Ping injection, a traditional Chinese medicine and an ancillary drug in tumor treatment, enhances the antitumor effects of cisplatin on Lewis lung cancer (LLC) cells. Methods. LLC-bearing mice were daily intraperitoneally injected with various doses of cisplatin, Xiao-Ai-Ping, or cisplatin plus Xiao-Ai-Ping, respectively. Body weight and tumor volumes were measured every three days. Results. Combination of Xiao-Ai-Ping and cisplatin yielded significantly better antigrowth and proapoptotic effects on LLC xenografts than sole drug treatment did. In addition, we found that Xiao-Ai-Ping triggered the infiltration of CD8~+ T cells, a group of cytotoxic T cells, to LLC xenografts. Furthermore, the mRNA levels of interferon-gamma (ifn-gamma), perforin-1 (prf-1), and granzyme B (gzmb) in CD8~+ T cells were significantly increased after combination treatment of Xiao-Ai-Ping and cisplatin. In vitro studies showed that Xiao-Ai-Ping markedly upregulated the mRNA levels of ifn-y, prf-1, and gzmb in CD8~+ T cells in a concentration-dependent manner, suggesting that Xiao-Ai-Ping augments the function of CD8~+ T cells. Conclusions. Xiao-Ai-Ping promotes the infiltration and function of CD8~+ T cells and thus enhances the antigrowth effects of cisplatin on LLC xenografts, which provides new evidence for the combination of Xiao-Ai-Ping and cisplatin in clinic in China.
机译：目标。为了研究小爱平注射液（一种用于治疗肿瘤的中药和辅助药物）如何增强顺铂对Lewis肺癌（LLC）细胞的抗肿瘤作用。方法。每天向腹腔注射的LLC小鼠分别腹腔注射各种剂量的顺铂，小爱平或顺铂加小爱平。每三天测量一次体重和肿瘤体积。结果。与单一药物治疗相比，小爱平和顺铂的组合对LLC异种移植物产生了显着更好的抗生长和促凋亡作用。此外，我们发现，小爱萍触发了一组细胞毒性T细胞CD8〜+ T细胞向LLC异种移植的浸润。此外，小艾平和顺铂联合治疗后，CD8〜+ T细胞中干扰素-γ（ifn-γ），穿孔素-1（prf-1）和颗粒酶B（gzmb）的mRNA水平显着增加。 。体外研究表明，小艾平显着上调CD8〜+ T细胞中ifn-y，prf-1和gzmb的mRNA水平，并呈浓度依赖性，这表明小艾平可增强CD8〜+ T细胞的功能。 CD8〜+ T细胞结论小爱平促进CD8〜+ T细胞的浸润和功能，从而增强顺铂对LLC异种移植物的抗生长作用，这为小爱平与顺铂联合应用提供了新的证据。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号