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首页> 外文期刊>Evidence-based dentistry >Local antimicrobials in addition to scaling and root planing provide statistically significant but not clinically important benefit
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Local antimicrobials in addition to scaling and root planing provide statistically significant but not clinically important benefit

机译：除结垢和根部平整外，局部抗菌剂还具有统计学上的显着优势，但在临床上并不重要

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Numerous clinical studies have shown that thorough mechanical debridement (ie scaling and root planing) is quite effective in the management of most cases of chronic periodontitis. The principle behind this is that disruption of the plaque biofilm and removal of local factors that harbour periodontal pathogens results in a reduction in periodontal inflammation and pocket depth - facilitating home care by the patient. However, subgingival debridement is a time-consuming and difficult procedure, highly dependent upon the skill of the clinician.1-2 Even when meticulously performed it does not necessarily eliminate pathogenic bacteria from the subgingival site. This is the basis for the rationale that the adjunctive use of antimicrobials could benefit patients with aggressive or refractory disease as well as those with local sites of disease. Local antimicrobials are particularly appealing as they do not carry the same risk of patient sensitivity and bacterial resistance associated with systemic antibiotics. For over 20 years, various classes of drugs and systems of drug delivery have been investigated to complement mechanical debridement.
机译：大量临床研究表明，彻底的机械清创术（即刮治和根部平整）在大多数慢性牙周炎病例的治疗中非常有效。其背后的原理是，斑块生物膜的破坏和带有牙周病原体的局部因子的去除导致牙周炎症和袋深度的减少，从而促进了患者的家庭护理。但是，龈下清创术是一个耗时且困难的过程，高度依赖于临床医生的技能。1-2即使精心执行，也不一定能从龈下部位清除病原菌。这是辅助使用抗生素可以使侵略性或难治性疾病以及局部疾病患者受益的基本原理。局部抗菌剂特别吸引人，因为它们不具有与全身性抗生素相关的患者敏感性和细菌耐药性的相同风险。 20多年来，人们对各种药物和药物输送系统进行了研究，以补充机械清创术。

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