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首页> 外文期刊>Evidence-based dentistry >Water fluoridation and Down's syndrome evidence inconclusive.
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Water fluoridation and Down's syndrome evidence inconclusive.

机译：水氟化和唐氏综合症的证据尚无定论。

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DATA SOURCES: A qualified librarian searched 25 specialist databases, including Medline, Embase, Toxline and the Current Contents Science Citation Index, from database inception to February 2000. In addition, searches of Index Medicus (1945-1959) and Excerpta Medica (1955-1973) were undertaken by hand. Additional references were sought from individuals and organisations through a dedicated website for this review [www.york.ac.uk/inst/crd/fluoride.htm], and through members of a specifically designated advisory panel. Published and unpublished studies in any language were included. STUDY SELECTION: All study designs were included that compared the incidence of Down's syndrome in populations where different levels of fluoride occurred in water supplies, either naturally or added artificially. DATA EXTRACTION AND SYNTHESIS: Two reviewers independently assessed each paper for inclusion, and disagreements were resolved through consensus. A qualitative analysis was conducted. RESULTS: The six studies includedwere all ecological in design and had poor validity scores. The estimates of the crude relative risk ranged from 0.84 to 3.0. Four studies showed no significant association between the incidence of Down's syndrome and water fluoride level whereas two studies by the same author found a significant (P<0.05) positive association (increased Down's syndrome incidence with increased water fluoride level). Only two of the studies controlled for confounding factors and only one of these presented summary outcome measures. CONCLUSIONS: The evidence of an association between water fluoride level and Down's syndrome incidence is inconclusive. The quality of the studies included in the review was relatively low, however, and further high quality research is needed.
机译：数据来源：一名合格的图书馆员从数据库成立到2000年2月，搜索了25个专业数据库，包括Medline，Embase，Toxline和Current Contents Science Citation Index。此外，还检索了Index Medicus（1945-1959）和Excerpta Medica（1955-）。 （1973年）由人为承担。通过个人网站和本组织，通过专门的网站[www.york.ac.uk/inst/crd/fluoride.htm]，以及专门指定的咨询小组成员，寻求其他参考。包括以任何语言发表的和未发表的研究。研究选择：包括所有研究设计，这些研究比较了自然或人工添加的供水中氟化物含量不同的人群中唐氏综合症的发生率。数据提取与合成：两位审稿人独立评估每篇论文的纳入性，并通过共识解决了分歧。进行了定性分析。结果：这六项研究全部在设计上都具有生态学意义，并且有效性评分较差。粗略相对风险的估计范围为0.84至3.0。四项研究表明唐氏综合症的发病率与氟化氢水平之间没有显着相关性，而同一作者的两项研究发现显着（P <0.05）的正相关性（唐氏综合症发病率与氟化氢水平升高相关）。只有两项研究控制了混杂因素，其中只有一项研究提供了汇总结果指标。结论：水氟化物水平与唐氏综合症发病率之间存在关联的证据尚无定论。该评价中包括的研究质量相对较低，但是，需要进一步的高质量研究。

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