...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Evidence-based dentistry >Topical fluorides provide additional benefit when used with fluoride toothpaste.
【24h】

Topical fluorides provide additional benefit when used with fluoride toothpaste.

机译：当与氟化物牙膏一起使用时，局部氟化物可提供额外的好处。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

DATA SOURCES: Cochrane Oral Health Group's Trials Register (May 2000), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 2, 2000), MEDLINE (1966 to January 2000), plus several other databases. We handsearched journals, reference lists of articles and contacted selected authors and manufacturers. STUDY SELECTION: Randomized or quasi-randomized controlled trials with blind outcome assessment, comparing fluoride varnish, gel, mouthrinse, or toothpaste in combination with each other in children up to 16 years during at least 1 year. The main outcome was caries increment measured by the change in decayed, missing and filled tooth surfaces (D(M)FS). DATA EXTRACTION AND SYNTHESIS: Inclusion decisions, quality assessment and data extraction were duplicated in a random sample of one third of studies, and consensus achieved by discussion or a third party. Authors were contacted for missing data. The primary measure of effect was the prevented fraction (PF) that is the difference in mean caries increments between the 'treatment' and 'control' groups expressed as a percentage of the mean increment in the control group. Random effects meta-analyses were performed where data could be pooled. RESULTS: Eleven of the 12 included studies contributed data for meta-analyses. Nine trials (4026 children) provided data for the main meta-analysis on the effect of fluoride mouthrinses, gels or varnishes used in combination with toothpaste. The D(M)FS pooled PF was 10% (95% CI, 2-17%; p=0.01) in favour of the combined regimens. There was no substantial heterogeneity. The estimated benefit equates to a number needed to treat (NNT) of 4 to avoid one decayed, filled or missing tooth surface (DMFS) per year in a child population with a caries increment of 2.5 D(M)FS per year, or an NNT of 13 for children from a population with a caries increment of 0.8 D(M)FS per year.Meta-analyses of fluoride gel or mouthrinse combined with toothpaste versus toothpaste alone favour the combined regimens, butdifferences were not statistically significant; the significant difference in favour of the combined use of fluoride varnish and toothpaste accrues from a very small trial and appears likely to be a spurious result. Not all other combinations of possible practical value were tested in the included studies. The only other statistically significant result was in favour of the combined use of fluoride gel and mouthrinse in comparison to gel alone (pooled DMFS PF 23%; 95% CI, 4-43%; p=0.02), based on two trials. No other combinations of TFT were consistently superior to a single TFT. CONCLUSIONS: Topical fluorides (mouthrinses, gels, or varnishes) used in addition to fluoride toothpaste achieve a modest reduction in caries compared to toothpaste used alone. No conclusions about any adverse effects could be reached, because data were scarcely reported in the trials.
机译：数据来源：Cochrane口腔健康小组的试验登记册（2000年5月），Cochrane对照试验中央登记册（CENTRAL）（2000年第2期Cochrane图书馆），MEDLINE（1966年至2000年1月）以及其他几个数据库。我们手工搜索期刊，文章参考列表，并与选定的作者和制造商联系。研究选择：具有盲目的结果评估的随机或半随机对照试验，比较至少1年以下16岁以下儿童中氟化物清漆，凝胶，漱口水或牙膏的组合。主要结果是龋齿增加，其通过龋齿表面的缺失，缺失和填充（D（M）FS）的变化来衡量。数据提取与合成：纳入决策，质量评估和数据提取在三分之一研究的随机样本中重复进行，并通过讨论或第三方达成共识。与作者联系以获取缺少的数据。疗效的主要指标是预防分数（PF），即“治疗”组和“对照组”之间平均龋齿增量的差异，表示为对照组中平均龋齿增量的百分比。在可以汇总数据的地方进行随机效应荟萃分析。结果：12项纳入研究中的11项为荟萃分析提供了数据。九项试验（4026名儿童）提供了有关与牙膏一起使用的氟化物漱口水，凝胶或清漆的作用的主要荟萃分析数据。 D（M）FS合并的PF为10％（95％CI，2-17％; p = 0.01），有利于合并方案。没有实质性的异质性。估计的收益等于每年需要龋齿增加2.5 D（M）FS的儿童群体中需要治疗的次数（NNT）为4，以避免每年出现一个龋齿，填充或缺失的牙齿表面（DMFS），或者每年龋齿增量为0.8 D（M）FS的儿童的NNT为13。氟化物或漱口水联合牙膏与单独使用牙膏的荟萃分析偏爱联合方案，但差异无统计学意义;一次很小的试验就得出了氟化物清漆和牙膏联合使用的显着差异，这似乎是虚假的结果。在纳入的研究中并未测试所有可能具有实用价值的其他组合。根据两项试验，唯一的统计学上显着的结果是与单独使用凝胶（合并DMFS PF 23％; 95％CI，4-43％; p = 0.02）相比，氟化物凝胶和漱口水的联合使用更为有利。 TFT的其他组合都没有一贯优于单个TFT。结论：与单独使用的牙膏相比，除氟化物牙膏外使用的局部氟化物（漱口水，凝胶或清漆）可减少龋齿。由于几乎没有试验报告数据，因此无法得出任何不良反应的结论。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号