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首页> 外文期刊>Experimental Physiology >Can physical exercise during gestation attenuate the effects of a maternal perinatal low-protein diet on oxygen consumption in rats?
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Can physical exercise during gestation attenuate the effects of a maternal perinatal low-protein diet on oxygen consumption in rats?

机译:妊娠期间进行体育锻炼是否可以减弱母体围产期低蛋白饮食对大鼠耗氧量的影响?

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摘要

A protocol of physical exercise, based on maximal oxygen uptake (Vo2max) for female rats before and during pregnancy was developed to evaluate the impact of a low-protein diet on oxygen consumption during gestation and growth rate of the offspring. Virgin female Wistar rats were divided into four groups as follows: untrained (NT, n = 5); trained (T, n = 5); untrained with low-protein diet (NT+LP, n = 5); and trained with low-protein diet (T+LP, n = 5). Trained rats were submitted to a protocol of moderate physical training on a treadmill over a period of 4 weeks (5 days week~(-1) and 60 min day~(-1), at 65% of Vo2max)- At confirmation of pregnancy, the intensity and duration of the exercise was reduced. Low-protein groups received an 8% casein diet, and their peers received a 17% casein diet. The birth weight and growth rate of the pups up to the 90th day were recorded. Oxygen consumption (Vo2), CO2 production and respiratory exchange ratio (RER) were determined using an indirect open-circuit calorimeter. Exercise training increased Vo2max by about 20% when compared with the initial values (45.6+-1.0 ml kg~(-1) min~(-1)). During gestation, all groups showed a progressive reduction in the resting Vo2 values. Dams in the NT+LP group showed lower values of resting Vo2 than those in the NT group. The growth rate of pups from low-protein-fed mothers was around 50% lower than that of their respective controls. The T group showed an increase in body weight from the 60th day onwards, while the NT+LP group presented a reduced body weight from weaning onwards. In conclusion, physical training attenuated the impact of the low-protein diet on oxygen consumption during gestation and on the growth rate of the offspring.
机译:根据怀孕之前和怀孕期间雌性大鼠的最大摄氧量(Vo2max),制定了一项体育锻炼方案,以评估低蛋白饮食对妊娠期和后代生长过程中耗氧量的影响。原始雌性Wistar大鼠分为以下四组:未经训练的(NT,n = 5);训练有素(T,n = 5);未经过低蛋白饮食训练(NT + LP,n = 5);并接受低蛋白饮食训练(T + LP,n = 5)。经过训练的大鼠在跑步机上接受了为期4周(每周5天〜(-1)和60分钟一天〜(-1),最大Vo2max的65%)的中等体育锻炼的方案-确认怀孕,减少了运动强度和持续时间。低蛋白组的饮食中酪蛋白含量为8%,同龄人的酪蛋白含量为17%。记录直至90天的幼仔的出生体重和生长速度。使用间接开路热量计确定氧气消耗量(Vo2),二氧化碳产生量和呼吸交换率(RER)。与初始值(45.6±1.0 ml kg〜(-1)min〜(-1))相比,运动训练可增加Vo2max约20%。妊娠期间,所有组均显示静息Vo2值逐渐降低。 NT + LP组的水坝静息Vo2值低于NT组。低蛋白喂养的母亲的幼崽的生长速度比其相应的对照组低约50%。从第60天开始,T组的体重增加,而从断奶开始,NT + LP组的体重减少。总之,体育锻炼减弱了低蛋白饮食对妊娠期间耗氧量以及对后代生长速率的影响。

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