...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Experimental Physiology >Cortisol and ACTH responses to severe asphyxia in preterm fetal sheep.
【24h】

Cortisol and ACTH responses to severe asphyxia in preterm fetal sheep.

机译：皮质醇和促肾上腺皮质激素对早产胎羊严重窒息的反应。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

It has been hypothesized that the hypothalamic-pituitary-adrenal (HPA) axis is immature in the preterm fetus and that this compromises their ability to adapt to hypoxic stress; however, there are few direct data. We therefore examined the effects of asphyxia on HPA responses in chronically instrumented preterm fetal sheep (104 days of gestation; term is 147 days), allocated to a sham control group (n = 7) or 25 min of complete umbilical cord occlusion (n = 8), followed by recovery for 72 h. During umbilical cord occlusion there was a rapid rise in ACTH levels (230.4 +/- 63.5 versus 14.1 +/- 1.8 ng ml(-1) in sham controls, 16-fold) and cortisol levels (7.4 +/- 4.9 versus 0.2 +/- 0.1 ng ml(-1), 31-fold), with further increases after release of cord occlusion. ACTH levels were normalized by 24 h, while plasma cortisol levels returned to sham control values 72 h after asphyxia. Fetal arterial blood pressure was elevated in the first 36 h, with a marked increase in femoral vascular resistance, and correlated positively with cortisol levels after asphyxia (P = 0.05). In conclusion, the preterm fetus shows a brisk, substantial HPA response to severe hypoxia.
机译：据推测，下丘脑-垂体-肾上腺（HPA）轴在早产胎儿中不成熟，这损害了它们适应低氧应激的能力。但是，直接数据很少。因此，我们检查了窒息对慢性器械早产羊（妊娠104天;任期为147天）分配给假对照组（n = 7）或完全脐带闭塞25分钟（n = 8），然后恢复72小时。在脐带闭塞期间，ACTH水平迅速增加（假手术对照组为230.4 +/- 63.5 vs 14.1 +/- 1.8 ng ml（-1），为16倍）和皮质醇水平（7.4 +/- 4.9 vs 0.2 + /-0.1 ng ml（-1），为31倍），在释放脐带闭塞后进一步增加。窒息后72 h，ACTH水平恢复正常，而血浆皮质醇水平恢复至假对照值。胎儿的动脉血压在最初的36小时内升高，股血管阻力显着增加，并且与窒息后的皮质醇水平呈正相关（P = 0.05）。总之，早产胎儿对严重的缺氧表现出轻快，大量的HPA反应。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号