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首页> 外文期刊>Experimental Physiology >Early response of heat shock proteins to functional overload of the soleus and plantaris in rats and mice.
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Early response of heat shock proteins to functional overload of the soleus and plantaris in rats and mice.

机译：热激蛋白对大鼠和小鼠比目鱼和足底功能超负荷的早期反应。

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Heat shock proteins (HSPs) are important factors in the response of skeletal muscles to chronic increases or decreases in activation and loading. The purpose of this study was to compare species-, time- and muscle-dependent changes in protein expression of Hsp20, Hsp25, alphaB-crystallin, Hsp72 and Hsp90 in response to functional overload (FO) in rats and mice. We compared protein levels of Hsp20, Hsp25, alphaB-crystallin, Hsp72 and Hsp90 in soleus and plantaris in baseline conditions and following 0.5, 1, 2, 3 and 7 days (rats) or 3 and 7 days (mice) of FO. Baseline levels of all HSPs were higher in rat soleus than plantaris, whereas only baseline expression of Hsp20 was higher in mouse soleus than plantaris. Levels of Hsp72 and Hsp90 were higher in plantaris and soleus of FO than control mice and rats after 3 and 7 days of FO. Protein levels and phosphorylation of Hsp25 in mouse plantaris and soleus were higher than control levels after 3 and 7 days of FO, except for soleus at 3 days. alphaB-crystallin levels were higher in plantaris of FO than control mice after 3 and 7 days of FO and in FO than control rats after 7 days of FO. Heat shock protein 20 was the least responsive, increasing only in 7 day FO rat plantaris compared with control rats. Overall, the results demonstrate that levels of both large and small HSPs increase with FO, suggesting a contributory role during the compensatory hypertrophy response.
机译：热休克蛋白（HSP）是骨骼肌对激活和负荷的慢性增加或减少的反应中的重要因素。这项研究的目的是比较大鼠和小鼠中功能性超负荷（FO）对Hsp20，Hsp25，alphaB-crystallin，Hsp72和Hsp90蛋白表达的物种，时间和肌肉依赖性变化。我们比较了基线条件下和比目鱼在0.5、1、2、3和7天（大鼠）或3和7天（小鼠）后的比目鱼和足底中Hsp20，Hsp25，αB-晶状蛋白，Hsp72和Hsp90的蛋白水平。大鼠比目鱼中所有HSP的基线水平均高于plant鱼，而比目鱼中只有Hsp20的基线表达高于小鼠比目鱼。 FO 3天和7天后，FO足底和比目鱼肌中Hsp72和Hsp90的水平高于对照小鼠和大鼠。 FO 3天和7天后，比目鱼在3天时，小鼠足底和比目鱼中Hsp25的蛋白质​​水平和磷酸化高于对照水平。 FO 3天和7天后，FO足底中的alphaB-晶状体蛋白水平高于对照组，而FO 7天后，FO中的αB-晶状体蛋白水平高于对照组。与对照组大鼠相比，热休克蛋白20的反应性最低，仅在FO大鼠7天足底增加。总体而言，结果表明，大，小HSP的水平均随FO的增加而增加，提示在代偿性肥大反应中起一定作用。

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