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首页> 外文期刊>Expert opinion on biological therapy >Perivascular cells as mesenchymal stem cells.
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Perivascular cells as mesenchymal stem cells.

机译：血管周细胞为间充质干细胞。

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IMPORTANCE OF THE FIELD: Mesenchymal stem cells are multipotent adult stem cell populations that have broad differentiation plasticity and immunosuppressive potential that render them of great importance in cell-based therapies. They are identified by in vitro characteristics based on their differentiation potential for clinical approaches while their biological properties and in vivo identities are often less understood. AREAS COVERED IN THIS REVIEW: Recent research carried out in the last decade on mesenchymal stem cell biology suggests that mesenchymal stem cells from various tissues reside in a perivascular location and these can be identified as pericytes that function as mural cells in microvessels. WHAT THE READER WILL GAIN: This review covers recent progress on understanding the link between pericytes and mesenchymal stem cells discussing specific points such as response to injury and tissue-specific functions. TAKE HOME MESSAGE: Despite a long and controversial history, there is a growing acceptance that perivascular cells are connected with mesenchymal stem cells, all that is really lacking is genetic evidence to show differentiation of pericytes into different cells types.
机译：领域的重要性：间充质干细胞是多能成人干细胞群体，具有广泛的分化可塑性和免疫抑制潜力，这使其在基于细胞的治疗中具有重要意义。根据它们在临床方法中的分化潜力，通过体外特征对其进行鉴定，而对其生物学特性和体内身份的了解往往很少。综述中涉及的领域：近十年来对间充质干细胞生物学进行的最新研究表明，来自各种组织的间充质干细胞位于血管周围位置，这些可以被鉴定为在微血管中起壁细胞作用的周细胞。读者的收获：这篇综述涵盖了在了解周细胞与间充质干细胞之间的联系方面的最新进展，并讨论了诸如损伤反应和组织特定功能的特定观点。温馨提示：尽管历史悠久且争议不断，但越来越多的人接受血管周细胞与间充质干细胞的连接，而真正缺乏的只是遗传证据显示周细胞分化为不同的细胞类型。

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