...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Expert opinion on biological therapy >Improvements in diagnosis of histoplasmosis.
【24h】

Improvements in diagnosis of histoplasmosis.

机译：改善组织胞浆菌病的诊断。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Understanding the uses and limitations of a battery of laboratory methods is essential to diagnose histoplasmosis. Antigen detection and serology are valuable adjuncts to histopathology and culture. Improvements incorporated into the second-generation Histoplasma antigen assay have increased its sensitivity and specificity for diagnosis of histoplasmosis. More recently, the antigen assay has been modified to provide quantitation, which improves reproducibility and facilitates monitoring antigen clearance during treatment. Furthermore, detection of antigen in bronchoalveolar lavage fluid increases the sensitivity for diagnosis of pulmonary histoplasmosis. Serological tests for antibodies are also useful, but may be falsely negative in immunosuppressed patients. In addition, elevated antibody titres persist for several years following initial infection, complicating their interpretation. Although histopathology may provide for rapid diagnosis, its sensitivity is < 50% in patients with disseminated disease and even lower in pulmonary histoplasmosis. Polymerase chain reaction has been described, but sensitivity is less than that of histopathology. Culture, although highly specific, has notable limitations, including insensitivity, a need for invasive procedures and delayed growth. This review provides the background for understanding the role of a battery of diagnostic methods in histoplasmosis. Tests facilitating a rapid diagnosis are expected to improve the outcome in patients with severe disease.
机译：了解一系列实验室方法的用途和局限性对于诊断组织胞浆菌病至关重要。抗原检测和血清学是组织病理学和文化的重要辅助手段。第二代组织胞浆抗原测定法的改进提高了其诊断组织胞浆菌病的敏感性和特异性。最近，对抗原测定法进行了改进以提供定量，从而提高了可重复性并有助于在治疗过程中监测抗原清除率。此外，支气管肺泡灌洗液中抗原的检测增加了诊断肺组织胞浆菌病的敏感性。抗体的血清学检查也很有用，但在免疫抑制的患者中可能会假阴性。另外，最初的感染后，抗体滴度升高持续了数年，使它们的解释变得复杂。尽管组织病理学可以提供快速诊断，但对于散播性疾病患者，其敏感性<50％，而肺组织胞浆病的敏感性甚至更低。已经描述了聚合酶链反应，但是敏感性小于组织病理学的敏感性。文化虽然具有高度的特异性，但有明显的局限性，包括不敏感，需要侵入性程序和生长迟缓。这篇综述为理解一系列诊断方法在组织胞浆菌病中的作用提供了背景。预期有助于快速诊断的测试将改善重症患者的预后。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号