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首页> 外文期刊>Expert opinion on biological therapy >Evaluating the role of IL-12 based therapies in ovarian cancer: a review of the literature.
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Evaluating the role of IL-12 based therapies in ovarian cancer: a review of the literature.

机译：评价基于IL-12的疗法在卵巢癌中的作用：文献综述。

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INTRODUCTION: Immunotherapy, in its entirety, represents a promising field at the forefront of cancer. Treatment with potent cytokine IL-12 has provided science with many challenges, but has also demonstrated promise as therapeutic strategy in ovarian cancer. AREAS COVERED: This review examines the anti-tumor mechanism of action of IL-12 and the development of IL-12 as a potential therapeutic option in a variety of malignancies. It also reviews the immunogenicity of ovarian cancer and covers preclinical and clinical trials that have contributed to the advancement of IL-12 as a potential therapy for ovarian malignancy. The obstacles that researchers have overcome and currently face regarding the use of IL-12 in clinical ovarian cancer trials are also discussed. EXPERT OPINION: IL-12, as a therapeutic modality, is mechanistically logical and shows great promise in preclinical trials. Further clinical studies are warranted to optimize the potential of IL-12 as a treatment strategy for ovarian cancer.
机译：简介：免疫疗法整体上代表了癌症领域最有希望的领域。用有效的细胞因子IL-12进行治疗已给科学带来了许多挑战，但也显示出有望作为卵巢癌的治疗策略。覆盖的领域：这篇综述检查了IL-12的抗肿瘤作用机制以及IL-12在多种恶性肿瘤中的潜在治疗选择。它还审查了卵巢癌的免疫原性，并涵盖了有助于提高IL-12作为卵巢恶性肿瘤潜在疗法的临床前和临床试验。还讨论了研究人员已经克服并目前在临床卵巢癌试验中使用IL-12所面临的障碍。专家意见：IL-12作为一种治疗方法，具有机械逻辑，在临床前试验中显示出巨大的希望。有必要进行进一步的临床研究，以优化IL-12作为卵巢癌治疗策略的潜力。

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