Vectors and strategies for nonviral cancer gene therapy

Pahle Jessica; Walther Wolfgang

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Vectors and strategies for nonviral cancer gene therapy

机译：非病毒癌基因治疗的载体和策略

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Introduction: This review presents recent developments in the use of nonviral vectors and transfer technologies in cancer gene therapy. Tremendous progress has been made in developing cancer gene therapy in ways that could be applicable to treatments. Numerous efforts are focused on methods of attacking known and novel targets more efficiently and specifically. In parallel to progress in nonviral vector design and delivery technologies, important achievements have been accomplished for suicide, gene replacement, gene suppression and immunostimulatory therapies. New nonviral cancer gene therapies have been developed based on emerging RNAi (si/shRNA-, miRNA) or ODN.

机译：简介：本综述介绍了在癌症基因治疗中使用非病毒载体和转移技术的最新进展。在开发癌症基因疗法方面已经取得了巨大的进展，可以应用于治疗。许多努力集中在更有效和更具体地攻击已知和新颖目标的方法上。在非病毒载体设计和递送技术进步的同时，自杀，基因替代，基因抑制和免疫刺激疗法也取得了重要成就。基于新兴的RNAi（si / shRNA-，miRNA）或ODN，已经开发了新的非病毒癌基因疗法。

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《Expert opinion on biological therapy》 |2016年第4期|共19页
作者
Pahle Jessica; Walther Wolfgang;
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原文格式 PDF
正文语种 eng
中图分类治疗学;
关键词
nonviral vectors; Cancer; gene transfer; Gene therapy;

机译：非病毒载体;癌症;基因转移;基因治疗;

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1. Vectors and strategies for nonviral cancer gene therapy [J] . Pahle Jessica, Walther Wolfgang Expert opinion on biological therapy . 2016,第4期

机译：非病毒癌基因治疗的载体和策略
2. Nonviral Vectors for Cancer Gene Therapy: Prospects for Integrating Vectors and Combination Therapies [J] . John R. Ohlfest Andrew B. Freese David A. Largaespada Current Gene Therapy . 2005,第6期

机译：癌症基因治疗的非病毒载体：整合载体和联合疗法的前景
3. A review of RGD-functionalized nonviral gene delivery vectors for cancer therapy [J] . J Park, K Singha, S Son, Cancer gene therapy . 2012,第11期

机译：RGD功能化的非病毒基因递送载体用于癌症治疗的综述
4. Nonviral gene administration by means of the Epstein-Barr virus (EBV)-based episomal vectors and it application to gene therapy and regenerative medicine [C] . Mazda O., Kishida T., Matsui M., Micro-NanoMechatronics and Human Science, 2009. MHS 2009 . 2009

机译：通过基于爱泼斯坦-巴尔病毒（EBV）的附加型载体进行非病毒基因管理及其在基因治疗和再生医学中的应用
5. A platform for next-generation cancer therapies: multi-targeted nonviral vectors for site-specific gene delivery and expression. [D] . Adil, Maroof Mohammad. 2013

机译：下一代癌症治疗的平台：用于位点特异性基因递送和表达的多目标非病毒载体。
6. Gene Therapy: Dual Supramolecular Nanoparticle Vectors Enable CRISPR/Cas9‐Mediated Knockin of Retinoschisin 1 Gene—A Potential Nonviral Therapeutic Solution for X‐Linked Juvenile Retinoschisis (Adv. Sci. 10/2020) [O] . Shih‐Jie Chou, Peng Yang, Qian Ban, 2020

机译：基因治疗：双超分子纳米载体可实现CRISPR / Cas9介导的视黄酸镰刀菌素1基因的敲除-一种潜在的非病毒性X线连接型青少年视骨镰刀菌病的解决方案（Adv。Sci。10/2020）
7. Revisiting Cationic Phosphorus Dendrimers as a Nonviral Vector for Optimized Gene Delivery Toward Cancer Therapy Applications [O] . -1

机译：重新探测阳离子磷树枝状大分子作为非血管载体，以优化癌症治疗应用的优化基因
8. Gene Therapy of Breast Cancer: Studies of Selective Promoter/Enhancer-Modified Vectors to Deliver Suicide Genes [R] . Kufe, D. W. 1998

机译：乳腺癌的基因治疗：选择性启动子/增强子修饰载体的研究，以提供自杀基因

Vectors and strategies for nonviral cancer gene therapy

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