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首页> 外文期刊>Expert opinion on biological therapy >Adalimumab for the treatment of severe psoriasis and psoriatic arthritis.
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Adalimumab for the treatment of severe psoriasis and psoriatic arthritis.

机译：阿达木单抗用于治疗严重的牛皮癣和牛皮癣关节炎。

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BACKGROUND: Psoriasis is a chronic, genetically determined, immunomediated, inflammatory skin disease affecting approximately 2 - 3% of the Caucasian population. Systemic treatment is required in moderate to severe plaque-type psoriasis forms or psoriatic arthritis. However, cumulative organ toxicity, lack of efficacy over time and other underlying diseases may limit long-term use of conventional treatments. OBJECTIVES: TNF-alpha, serves a key role in potentiating inflammatory responses associated with both psoriasis and psoriatic arthritis. Adalimumab is a fully human anti-TNF-alpha monoclonal antibody; approved for the treatment of psoriatic arthritis and, more recently, for plaque-type psoriasis. Methods: This review reports the latest progresses made in the clinical use of 'biologic' drugs for psoriasis focusing on the clinical management of adalimumab in the treatment of plaque psoriasis and psoriatic arthritis. RESULTS: Adalimumab was shown to be effective in treating both psoriasis and psoriaticarthritis with a rapid onset of action and a good safety profile.
机译：背景：牛皮癣是一种经遗传确定的，由免疫介导的慢性炎症性皮肤病，约占白种人的2％-3％。中度至重度斑块型牛皮癣形式或牛皮癣关节炎需要全身治疗。但是，累积的器官毒性，随着时间的推移缺乏疗效以及其他潜在疾病可能会限制长期使用传统疗法。目的：TNF-α在增强与牛皮癣和牛皮癣关节炎相关的炎症反应中起关键作用。阿达木单抗是一种完全人源的抗TNF-α单克隆抗体;批准用于治疗牛皮癣关节炎，最近用于斑块型牛皮癣。方法：这篇综述报告了“生物”药物治疗牛皮癣的最新进展，重点是阿达木单抗治疗斑块状牛皮癣和牛皮癣关节炎的临床管理。结果：阿达木单抗被证明可有效治疗银屑病和牛皮癣，起效快，安全性好。

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