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首页> 外文期刊>Expert opinion on biological therapy >Oncophage: step to the future for vaccine therapy in melanoma.
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Oncophage: step to the future for vaccine therapy in melanoma.

机译：噬菌体：迈向黑色素瘤疫苗治疗的未来。

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Heat-shock proteins (HSPs) are a group of proteins whose expression is increased when the cells are exposed to elevated temperatures or other stressful conditions. This increase in expression is transcriptionally regulated. The function of HSPs is similar in virtually all living organisms, from bacteria to humans. Their expression also occur under non-stressful conditions, simply 'monitoring' the cell's proteins, i.e., they carry old proteins to the cell's 'recycling bin' and they help newly synthesized proteins fold properly. These activities are part of a cell's own repair system. HSPs are molecular chaperones for protein molecules. They are usually cytoplasmic proteins and they perform functions in various intracellular processes. Tumour-derived HSP-peptide complexes (HSPPCs) can be used for vaccination against malignancies. In particular, HSPPC-96 complex, called Vitespen (formerly Oncophage) is a HSPs-based vaccine made from individual patients' tumours with a promising role in cancer management. This vaccine has been extensively studied in Phase I and II clinical trials, showing activity on different malignancies, including gastric cancer, colorectal cancer, pancreatic cancer, non-Hodgkin's lymphoma and chronic myelogenous leukaemia. The vaccine has also been studied in Phase III clinical trials in melanoma and kidney cancer, showing an excellent safety profile with essentially no toxicity. Thus, HSP-based vaccines are a novel therapeutic approach with a promising role in cancer management.
机译：热休克蛋白（HSP）是一组蛋白质，当细胞暴露于高温或其他压力条件下，其表达会增强。表达的这种增加是转录调控的。从细菌到人类，几乎所有活生物体中HSP的功能都相似。它们的表达也可以在非压力条件下发生，只需“监测”细胞的蛋白质即可，即它们将旧蛋白质带到细胞的“回收箱”中，并帮助新合成的蛋白质正确折叠。这些活动是单元自身修复系统的一部分。 HSP是蛋白质分子的分子伴侣。它们通常是细胞质蛋白，并在各种细胞内过程中发挥功能。肿瘤来源的HSP肽复合物（HSPPC）可用于预防恶性肿瘤的疫苗接种。特别地，称为Vitespen（以前称为Oncophage）的HSPPC-96复合物是一种基于HSPs的疫苗，由个体患者的肿瘤制成，在癌症治疗中具有重要作用。该疫苗已在I和II期临床试验中进行了广泛研究，显示出对不同恶性肿瘤的活性，包括胃癌，结肠直肠癌，胰腺癌，非霍奇金淋巴瘤和慢性粒细胞性白血病。该疫苗还在黑色素瘤和肾癌的III期临床试验中进行了研究，显示出优异的安全性，基本没有毒性。因此，基于HSP的疫苗是一种新颖的治疗方法，在癌症治疗中具有广阔的前景。

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