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首页> 外文期刊>Expert opinion on biological therapy >Protective efficacy of different strategies employing Mycobacterium leprae heat-shock protein 65 against tuberculosis.
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Protective efficacy of different strategies employing Mycobacterium leprae heat-shock protein 65 against tuberculosis.

机译：采用麻风分枝杆菌热休克蛋白65的不同策略对肺结核的保护作用。

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摘要

BACKGROUND: Tuberculosis is a major threat to human health. The high disease burden remains unaffected and the appearance of extremely drug-resistant strains in different parts of the world argues in favor of the urgent need for a new effective vaccine. One of the promising candidates is heat-shock protein 65 when used as a genetic vaccine (DNAhsp65). Nonetheless, there are substantial data indicating that BCG, the only available anti-TB vaccine for clinical use, provides other important beneficial effects in immunized infants. METHODS: We compared the protective efficacy of BCG and Hsp65 antigens in mice using different strategies: i) BCG, single dose subcutaneously; ii) naked DNAhsp65, four doses, intramuscularly; iii) liposomes containing DNAhsp65, single dose, intranasally; iv) microspheres containing DNAhsp65 or rHsp65, single dose, intramuscularly; and v) prime-boost with subcutaneous BCG and intramuscular DNAhsp65. RESULTS: All the immunization protocols were able to protect mice against infection, with special benefits provided by DNAhsp65 in liposomes and prime-boost strategies. CONCLUSION: Among the immunization protocols tested, liposomes containing DNAhsp65 represent the most promising strategy for the development of a new anti-TB vaccine.
机译：背景：结核病是对人类健康的主要威胁。高疾病负担仍然没有受到影响，并且在世界不同地区出现的高度耐药菌株表明，迫切需要新的有效疫苗。当用作基因疫苗（DNAhsp65）时，有希望的候选药物之一是热激蛋白65。尽管如此，有大量数据表明，卡介苗是唯一可用于临床的抗结核疫苗，在免疫婴儿中提供了其他重要的有益作用。方法：我们比较了使用不同策略的BCG和Hsp65抗原对小鼠的保护作用：i）BCG，皮下单剂量; ii）肌肉内裸露DNAhsp65，四剂; iii）鼻内含单剂量DNAhsp65的脂质体; iv）肌内含有单剂量DNAhsp65或rHsp65的微球; v）皮下BCG和肌内DNAhsp65的初免-加强。结果：所有的免疫方案都能保护小鼠免受感染，其中DNAhsp65在脂质体和初免-加强策略中具有特殊优势。结论：在所测试的免疫方案中，含有DNAhsp65的脂质体是开发新型抗结核疫苗的最有希望的策略。

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