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Non-neutralizing antibodies in prevention of HIV infection.

机译：非中和抗体可预防HIV感染。

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INTRODUCTION: One of the challenges facing the development of an AIDS vaccine is eliciting antibody (Ab) capable of preventing the acquisition of HIV. Broadly neutralizing Ab (bnAb) that can prevent HIV infection has proven to be difficult to elicit. Here, we consider the potential for protective non-neutralizing Ab (pnnAb) to provide the much needed Ab component for an HIV vaccine. Such Ab acts by "tagging" virus or infected cells for destruction by the innate immune system. AREAS COVERED: We review interactions between the Fc region of immunoglobulin G (IgG) and Fc? receptors or complement that can lead to the destruction of HIV or HIV-infected cells, correlations between the presence of pnnAb and the prevention of HIV and simian immunodeficiency virus (SIV) infections, differences between classical HIV-specific bnAb and HIV-specific pnnAb, HIV envelope antigens and adjuvants which have been hypothesized to generate pnnAb, and the use of avidity as a serological correlate for pnnAb. EXPERT OPINION: We hypothesize that selection of HIV for the poor ability to elicit bnAb has also selected it for slow entry into cells and a window of opportunity for pnnAb to tag virus for destruction by innate immune responses.
机译：简介：开发艾滋病疫苗面临的挑战之一是引发能够预防艾滋病毒感染的抗体（Ab）。事实证明，很难中和能够预防HIV感染的Ab（bnAb）。在这里，我们认为保护性非中和抗体（pnnAb）可以为HIV疫苗提供急需的Ab成分。这种抗体通过“标记”病毒或被感染的细胞以被先天免疫系统破坏而起作用。覆盖的区域：我们回顾了免疫球蛋白G（IgG）的Fc区与Fc的相互作用。可能导致HIV或HIV感染细胞破坏的受体或补体，pnnAb的存在与预防HIV和猿猴免疫缺陷病毒（SIV）感染之间的相关性，经典HIV特异性bnAb与HIV特异性pnnAb之间的差异， HIV包膜抗原和佐剂已被假定可产生pnnAb，并已将亲和力用作pnnAb的血清学相关性。专家意见：我们假设选择HIV的原因是它引起bnAb的能力较弱，因此也选择它来缓慢进入细胞，并且为pnnAb标记病毒以通过先天免疫应答进行破坏提供了机会。

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