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Epidermal stem cells: An update on their potential in regenerative medicine

机译：表皮干细胞：其在再生医学中的潜力的更新

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Introduction: Adult epidermal stem cells are crucial for skin tissue regeneration during homeostasis and disease. Recent updates relating to the function, cellular role and properties of these cells have been published. Notably, a recent study showed that keratinocytes may possess a transcriptional profile that is more amenable to reprogramming and this may open new avenues for exploring novel strategies to create patient-specific cell therapies. Areas covered: In this paper, an overview of recent research pertaining to epidermal stem cells' properties and location, and their capacity for differentiation and transdifferentiation, as well as potential for tumorigenesis are presented. Expert opinion: More efforts should be made to develop effective approaches to induce lineage conversion between different cell types and tailor the treatment to specific patient, while minimizing cancer risk.
机译：简介：成人表皮干细胞对于体内稳态和疾病期间皮肤组织的再生至关重要。与这些细胞的功能，细胞作用和性质有关的最新更新已经发表。值得注意的是，最近的一项研究表明，角质形成细胞可能具有更易于重编程的转录特征，这可能为探索新颖的策略以创建针对患者的细胞疗法开辟新途径。涵盖的领域：本文概述了与表皮干细胞的性质和位置有关的最新研究，以及它们的分化和转分化能力以及潜在的肿瘤发生能力。专家意见：应该做出更大的努力来开发有效的方法，以诱导不同细胞类型之间的谱系转换，并针对特定患者调整治疗方案，同时最大程度地降低癌症风险。

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