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首页> 外文期刊>Expert opinion on biological therapy >Oncolytic measles virus strains as novel anticancer agents.
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Oncolytic measles virus strains as novel anticancer agents.

机译：溶瘤性麻疹病毒株为新型抗癌药。

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Replication-competent oncolytic measles virus (MV) strains preferentially infect and destroy a wide variety of cancer tissues. Clinical translation of engineered attenuated MV vaccine derivatives is demonstrating the therapeutic potential and negligible pathogenicity of these strains in humans. AREAS COVERED: The present review summarizes the mechanisms of MV tumor selectivity and cytopathic activity as well as the current data on the oncolytic efficacy and preclinical testing of MV strains. Investigational strategies to reprogram MV selectivity, escape antiviral immunity and modulate the immune system to enhance viral delivery and tumor oncolysis are also discussed. EXPERT OPINION: Clinical viral kinetic data derived from noninvasive monitoring of reporter transgene expression will guide future protocols to enhance oncolytic MV efficacy. Anti-measles immunity is a major challenge of measles-based therapeutics and various strategies are being investigated to modulate immunity. These include the combination of MV therapy with immunosuppressive drugs, such as cyclophosphamide, the use of cell carriers and the introduction of immunomodulatory transgenes and wild-type virulence genes. Available MV retargeting technologies can address safety considerations that may arise as more potent oncolytic MV vectors are being developed.
机译：具有复制能力的溶瘤性麻疹病毒（MV）菌株优先感染并破坏多种癌症组织。工程化减毒的MV疫苗衍生物的临床翻译证明了这些菌株在人类中的治疗潜力和致病性可忽略不计。覆盖的领域：本综述总结了MV肿瘤选择性和细胞病变活性的机制，以及有关MV菌株的溶瘤功效和临床前测试的最新数据。还讨论了重新编程MV选择性，逃避抗病毒免疫力和调节免疫系统以增强病毒传递和肿瘤溶瘤作用的研究策略。专家意见：从无创监测报告基因转基因表达获得的临床病毒动力学数据将指导未来的方案，以提高溶瘤性MV的疗效。抗麻疹免疫是基于麻疹的治疗方法的主要挑战，目前正在研究各种调节免疫的策略。这些措施包括将MV治疗与免疫抑制剂（例如环磷酰胺）相结合，使用细胞载体以及引入免疫调节性转基因和野生型毒力基因。可用的MV重定向技术可以解决由于开发更有效的溶瘤MV载体而引起的安全考虑。

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