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首页> 外文期刊>Expert opinion on biological therapy >Can you vaccinate against substance abuse?
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Can you vaccinate against substance abuse?

机译：您可以预防滥用药物吗？

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Vaccines are being developed against substance abuse and most progress has been made with anti-cocaine, nicotine and opiate vaccines, but new ones are being developed for methamphetamine and may be in humans within 18-24 months. These haptenated vaccines share a common problem in that only about one-third of those vaccinated get a sufficiently robust antibody titer to enable them to effectively block drug use. This problem is being addressed with better carrier proteins and new adjuvants beyond alum. This review provides details about these developing vaccines that act through pharmacokinetic rather than pharmacodynamics blockade. Due to this phar-macokinetic mechanism of keeping abused drugs in the bloodstream and not allowing them entry into the brain or other organs, these vaccines have very few side effects compared to other blockers used in addictions treatment
机译：正在开发针对药物滥用的疫苗，抗可卡因，尼古丁和鸦片疫苗已取得了最大的进展，但是正在开发用于甲基苯丙胺的新疫苗，并且可能在18-24个月内在人体中使用。这些半抗原疫苗存在一个共同的问题，即仅三分之一的疫苗接种者获得了足够稳固的抗体滴度，从而能够有效地阻止药物使用。用更好的载体蛋白和明矾以外的新佐剂解决了这个问题。这篇综述提供了有关这些通过药代动力学而非药效动力学阻断作用发挥作用的新型疫苗的详细信息。由于这种药物代谢动力学机制可将滥用的药物保留在血液中，并且不允许它们进入大脑或其他器官，因此与成瘾治疗中使用的其他阻滞剂相比，这些疫苗几乎没有副作用

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