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Bispecific antibodies, nanoparticles and cells: bringing the right cells to get the job done

机译:双特异性抗体,纳米颗粒和细胞:带上正确的细胞来完成工作

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摘要

Pre-arming therapeutic cells with bispecific antibodies (BiAbs) before infusion can home the cells to specific tissue antigens in the body. With the development of nanotechnology, we developed a novel strategy, namely magnetic bispecific cell engager (MagBICE), that combines BiAbs with biodegradable iron nanoparticles. Compared to conventional BiAbs, the latter enables magnetic targeting and imaging. This editorial discusses current knowledge of BiAbs and their applications in targeting activated T cells to cancerous tissues or targeting bone marrow-derived stem cells to myocardial infarction. We will also discuss the fabrication of MagBICE and its application in treating rodents with myocardial infarction.
机译:输注前用双特异性抗体(BiAbs)预备治疗细胞可使细胞适应体内的特定组织抗原。随着纳米技术的发展,我们开发了一种新颖的策略,即磁性双特异性细胞接合剂(MagBICE),它将BiAbs与可生物降解的铁纳米颗粒结合在一起。与常规BiAb相比,后者可以实现磁性靶向和成像。这篇社论讨论了BiAbs的最新知识及其在将活化T细胞靶向癌组织或将骨髓来源干细胞靶向心肌梗塞中的应用。我们还将讨论MagBICE的制备及其在啮齿动物心肌梗塞治疗中的应用。

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