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Recommended screening and preventive evaluation practices of adult candidates for hematopoietic stem cell transplantation

机译：成人造血干细胞移植的推荐筛查和预防性评估方法

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Introduction: Hematopoietic stem cell transplantation (HSCT) is associated with a substantial risk of morbidity and mortality. Better selection of HSCT patients for intensive treatment, and consequently reduction of non-beneficial care, may improve the therapeutic outcome.Areas covered: This manuscript provides a systematic review which examines t he current criteria for selection of HSCT patients.Expert opinion: Identifying patients who may benefit from HSCT involves many factors, including overall health, prior therapies, age, disease, and stage. The decision regarding transplant eligibility should be made on a case by case basis, based on a risk-benefit assessment. The advent of the comorbidity index as a measure of health status at the time of HSCT has facilitated the incorporation of comorbidities into the pre-transplant assessment of patients. Many HSCT protocols are still age-dependent, with criteria limited to patients either younger or older than arbitrary age cut-offs.The prognostic role of age in the transplant setting has never been consistent. As physicians and researchers continue improving the HSCT process and outcomes, optimization of the delivery of a comprehensive treatment plan should become an important component of overall patient management.
机译：简介：造血干细胞移植（HSCT）与高发病率和死亡风险相关。更好地选择要接受深层治疗的HSCT患者，从而减少非受益性护理，可能会改善治疗效果。覆盖范围：本手稿提供了系统的综述，审查了当前选择HSCT患者的标准专家意见：确定患者谁可能受益于HSCT涉及许多因素，包括整体健康，先前的治疗方法，年龄，疾病和阶段。有关移植资格的决定应基于风险收益评估，逐案做出。在HSCT时，合并症指数作为一种健康状况的度量标准的出现促进了合并症在患者移植前评估中的应用。许多HSCT方案仍然取决于年龄，其标准仅限于年龄大于或等于任意年龄的患者。年龄在移植环境中的预后作用从未得到一致证实。随着医生和研究人员继续改善HSCT流程和结果，优化综合治疗计划的交付应成为整体患者管理的重要组成部分。

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