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A novel therapeutic paradigm for patients with extensive alopecia areata

机译:广泛性斑秃患者的新型治疗范例

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Introduction: Alopecia areata (AA) is a common, T-cell mediated, hair-centered skin disease that lacks efficacious, long-term therapies for extensive disease. Systemic immune suppressants are usually used, despite their nonspecific actions, often associated with substantial side effects. Although, the Th1 pathway was suggested as pivotal in the disease, recent studies suggest that Th2, Th9, phosphodiesterase (PDE) 4, and IL-23 axes might contribute to AA pathogenesis.
机译:简介:斑秃(AA)是一种常见的T细胞介导的以头发为中心的皮肤病,缺乏有效的长期治疗广泛性疾病的疗法。尽管具有非特异性作用,但通常仍使用全身性免疫抑制剂,这些副作用通常与严重的副作用有关。尽管Th1途径被认为是该疾病的关键,但最近的研究表明Th2,Th9,磷酸二酯酶(PDE)4和IL-23轴可能与AA发病机理有关。

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